TY - JOUR
T1 - Meta-analysis of the impact of mitral regurgitation on outcomes after transcatheter aortic valve implantation
AU - Chakravarty, Tarun
AU - Van Belle, Eric
AU - Jilaihawi, Hasan
AU - Noheria, Amit
AU - Testa, Luca
AU - Bedogni, Francesco
AU - Rück, Andreas
AU - Barbanti, Marco
AU - Toggweiler, Stefan
AU - Thomas, Martyn
AU - Khawaja, Muhammed Z eeshan
AU - Hutter, Andrea
AU - Abramowitz, Yigal
AU - Siegel, Robert J.
AU - Cheng, Wen
AU - Webb, John
AU - Leon, Martin B.
AU - Makkar, Raj R.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Significant mitral regurgitation (MR) constitutes an important co-existing valvular heart disease burden in the setting of aortic valve stenosis. There are conflicting reports on the impact of significant MR on outcomes after transcatheter aortic valve implantation (TAVI). We evaluated the impact of MR on outcomes after TAVI by performing a meta-analysis of 8 studies involving 8,927 patients reporting TAVI outcomes based on the presence or absence of moderate-severe MR. Risk ratios (RRs) were calculated using the inverse variance random-effects model. None-mild MR was present in 77.8% and moderate-severe MR in 22.2% of the patients. The presence of moderate-severe MR at baseline was associated with increased mortality at 30 days (RR 1.35, 95% confidence interval [CI] 1.14 to 1.59, p = 0.003) and 1 year (RR 1.24, 95% CI 1.13 to 1.37, p
AB - Significant mitral regurgitation (MR) constitutes an important co-existing valvular heart disease burden in the setting of aortic valve stenosis. There are conflicting reports on the impact of significant MR on outcomes after transcatheter aortic valve implantation (TAVI). We evaluated the impact of MR on outcomes after TAVI by performing a meta-analysis of 8 studies involving 8,927 patients reporting TAVI outcomes based on the presence or absence of moderate-severe MR. Risk ratios (RRs) were calculated using the inverse variance random-effects model. None-mild MR was present in 77.8% and moderate-severe MR in 22.2% of the patients. The presence of moderate-severe MR at baseline was associated with increased mortality at 30 days (RR 1.35, 95% confidence interval [CI] 1.14 to 1.59, p = 0.003) and 1 year (RR 1.24, 95% CI 1.13 to 1.37, p
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U2 - 10.1016/j.amjcard.2015.01.022
DO - 10.1016/j.amjcard.2015.01.022
M3 - Article
C2 - 25779617
AN - SCOPUS:84929513917
SN - 0002-9149
VL - 115
SP - 942
EP - 949
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 7
ER -