Mesenchymal stem cells: Potential for therapy and treatment of chronic non-healing skin wounds

Giovanni Marfia, Stefania Elena Navone, Clara Di Vito, Nicola Ughi, Silvia Tabano, Monica Miozzo, Carlo Tremolada, Gianni Bolla, Chiara Crotti, Francesca Ingegnoli, Paolo Rampini, Laura Riboni, Roberta Gualtierotti, Rolando Campanella

Research output: Contribution to journalArticlepeer-review


Wound healing is a complex physiological process including overlapping phases (hemostatic/inflammatory, proliferating and remodeling phases). Every alteration in this mechanism might lead to pathological conditions of different medical relevance. Treatments for chronic nonhealing wounds are expensive because reiterative treatments are needed. Regenerative medicine and in particular mesenchymal stem cells approach is emerging as new potential clinical application in wound healing. In the past decades, advance in the understanding of molecular mechanisms underlying wound healing process has led to extensive topical administration of growth factors as part of wound care. Currently, no definitive treatment is available and the research on optimal wound care depends upon the efficacy and cost-benefit of emerging therapies. Here we provide an overview on the novel approaches through stem cell therapy to improve cutaneous wound healing, with a focus on diabetic wounds and Systemic Sclerosis-associated ulcers, which are particularly challenging. Current and future treatment approaches are discussed with an emphasis on recent advances.

Original languageEnglish
Pages (from-to)183-206
Number of pages24
Issue number4
Publication statusPublished - Jan 1 2015


  • Adipose stem cells
  • Autoimmune diseases
  • Diabetes
  • Mesenchymal stem cells
  • Systemic sclerosis
  • Ulcer
  • Wound

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology
  • Transplantation
  • Biomedical Engineering


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