Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts

Paola Secchiero, Federica Corallini, Barbara Zavan, Claudio Tripodo, Vincenzo Vindigni, Giorgio Zauli

Research output: Contribution to journalArticlepeer-review


A disseminated model of non-Hodgkin's lymphoma with prevalent liver metastasis was generated by intraperitoneal (i.p.) injection of EBV + B lymphoblastoid SKW6.4 in nude-SCID mice. The survival of SKW6.4 xenografts (median survival = 27 days) was significantly improved when hyaluronan scaffolds embedded with mesenchimal stem cells (MSC) were implanted in the abdominal area 4 days after SKW6.4 injection (median survival = 39.5 days). Mice implanted with MSC showed a significant improvement of hepatic functionality in lymphoma xenografts, as demonstrated by measurement of serum ALT/AST levels. Co-culture of MSC with lymphoma cells enhanced the release of hepatocyte growth factor (HGF) by MSC. These data suggest that hyaluronanembedded MSC exert anti-lymphoma activity by ameliorating hepatic functionality.

Original languageEnglish
Pages (from-to)803-807
Number of pages5
JournalInvestigational New Drugs
Issue number2
Publication statusPublished - Apr 2012


  • Liver functionality
  • Lymphoma-bearing xenografts
  • Mesenchymal stem cells

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Oncology


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