Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts

Paola Secchiero; Federica Corallini; Barbara Zavan; Claudio Tripodo; Vincenzo Vindigni; Giorgio Zauli

doi:10.1007/s10637-010-9534-z

Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts

Paola Secchiero, Federica Corallini, Barbara Zavan, Claudio Tripodo, Vincenzo Vindigni, Giorgio Zauli

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

A disseminated model of non-Hodgkin's lymphoma with prevalent liver metastasis was generated by intraperitoneal (i.p.) injection of EBV ⁺ B lymphoblastoid SKW6.4 in nude-SCID mice. The survival of SKW6.4 xenografts (median survival = 27 days) was significantly improved when hyaluronan scaffolds embedded with mesenchimal stem cells (MSC) were implanted in the abdominal area 4 days after SKW6.4 injection (median survival = 39.5 days). Mice implanted with MSC showed a significant improvement of hepatic functionality in lymphoma xenografts, as demonstrated by measurement of serum ALT/AST levels. Co-culture of MSC with lymphoma cells enhanced the release of hepatocyte growth factor (HGF) by MSC. These data suggest that hyaluronanembedded MSC exert anti-lymphoma activity by ameliorating hepatic functionality.

Original language	English
Pages (from-to)	803-807
Number of pages	5
Journal	Investigational New Drugs
Volume	30
Issue number	2
DOIs	https://doi.org/10.1007/s10637-010-9534-z
Publication status	Published - Apr 2012

Keywords

Liver functionality
Lymphoma-bearing xenografts
Mesenchymal stem cells

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Oncology

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title = "Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts",

abstract = "A disseminated model of non-Hodgkin's lymphoma with prevalent liver metastasis was generated by intraperitoneal (i.p.) injection of EBV + B lymphoblastoid SKW6.4 in nude-SCID mice. The survival of SKW6.4 xenografts (median survival = 27 days) was significantly improved when hyaluronan scaffolds embedded with mesenchimal stem cells (MSC) were implanted in the abdominal area 4 days after SKW6.4 injection (median survival = 39.5 days). Mice implanted with MSC showed a significant improvement of hepatic functionality in lymphoma xenografts, as demonstrated by measurement of serum ALT/AST levels. Co-culture of MSC with lymphoma cells enhanced the release of hepatocyte growth factor (HGF) by MSC. These data suggest that hyaluronanembedded MSC exert anti-lymphoma activity by ameliorating hepatic functionality.",

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AU - Secchiero, Paola

AU - Corallini, Federica

AU - Zavan, Barbara

AU - Tripodo, Claudio

AU - Vindigni, Vincenzo

AU - Zauli, Giorgio

PY - 2012/4

Y1 - 2012/4

N2 - A disseminated model of non-Hodgkin's lymphoma with prevalent liver metastasis was generated by intraperitoneal (i.p.) injection of EBV + B lymphoblastoid SKW6.4 in nude-SCID mice. The survival of SKW6.4 xenografts (median survival = 27 days) was significantly improved when hyaluronan scaffolds embedded with mesenchimal stem cells (MSC) were implanted in the abdominal area 4 days after SKW6.4 injection (median survival = 39.5 days). Mice implanted with MSC showed a significant improvement of hepatic functionality in lymphoma xenografts, as demonstrated by measurement of serum ALT/AST levels. Co-culture of MSC with lymphoma cells enhanced the release of hepatocyte growth factor (HGF) by MSC. These data suggest that hyaluronanembedded MSC exert anti-lymphoma activity by ameliorating hepatic functionality.

AB - A disseminated model of non-Hodgkin's lymphoma with prevalent liver metastasis was generated by intraperitoneal (i.p.) injection of EBV + B lymphoblastoid SKW6.4 in nude-SCID mice. The survival of SKW6.4 xenografts (median survival = 27 days) was significantly improved when hyaluronan scaffolds embedded with mesenchimal stem cells (MSC) were implanted in the abdominal area 4 days after SKW6.4 injection (median survival = 39.5 days). Mice implanted with MSC showed a significant improvement of hepatic functionality in lymphoma xenografts, as demonstrated by measurement of serum ALT/AST levels. Co-culture of MSC with lymphoma cells enhanced the release of hepatocyte growth factor (HGF) by MSC. These data suggest that hyaluronanembedded MSC exert anti-lymphoma activity by ameliorating hepatic functionality.

KW - Liver functionality

KW - Lymphoma-bearing xenografts

KW - Mesenchymal stem cells

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Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts

Abstract

Keywords

ASJC Scopus subject areas

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