Men with COVID-19 die. Women survive

Virginia V. Ferretti; Catherine Klersy; Raffaele Bruno; Sara Cutti; Rossella E. Nappi

doi:10.1016/j.maturitas.2021.11.014

Men with COVID-19 die. Women survive

Virginia V. Ferretti, Catherine Klersy, Raffaele Bruno, Sara Cutti, Rossella E. Nappi

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

The severity and mortality rate of COVID-19 differ between the sexes. Several biopsychosocial determinants may account for the better outcomes in women. The notion that sex steroid hormones account for the gender disparity is reasonable but not proven; the same is true of the role of menopause as a risk factor. A retrospective analysis of patients (=1764) hospitalized in Italy showed a higher mortality (HR 1.58, 95%CI 1.30–1.91, adjusted for age and multi-comorbidities) in males only after the age of 65 (the rate is twice as high in the 65–79-year age group and 1.5-fold higher in those aged over 80). The higher mortality of men is mostly evident among those aged over 65 years, long after the average age of menopause.

Original language	English
Pages (from-to)	34-36
Number of pages	3
Journal	Maturitas
Volume	158
DOIs	https://doi.org/10.1016/j.maturitas.2021.11.014
Publication status	Published - Apr 2022

Keywords

Androgens
COVID-19
Estrogens
Gender
Menopause
SARS-Cov-2

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Obstetrics and Gynaecology

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10.1016/j.maturitas.2021.11.014

Cite this

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title = "Men with COVID-19 die. Women survive",

abstract = "The severity and mortality rate of COVID-19 differ between the sexes. Several biopsychosocial determinants may account for the better outcomes in women. The notion that sex steroid hormones account for the gender disparity is reasonable but not proven; the same is true of the role of menopause as a risk factor. A retrospective analysis of patients (=1764) hospitalized in Italy showed a higher mortality (HR 1.58, 95%CI 1.30–1.91, adjusted for age and multi-comorbidities) in males only after the age of 65 (the rate is twice as high in the 65–79-year age group and 1.5-fold higher in those aged over 80). The higher mortality of men is mostly evident among those aged over 65 years, long after the average age of menopause.",

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AU - Ferretti, Virginia V.

AU - Klersy, Catherine

AU - Bruno, Raffaele

AU - Cutti, Sara

AU - Nappi, Rossella E.

PY - 2022/4

Y1 - 2022/4

N2 - The severity and mortality rate of COVID-19 differ between the sexes. Several biopsychosocial determinants may account for the better outcomes in women. The notion that sex steroid hormones account for the gender disparity is reasonable but not proven; the same is true of the role of menopause as a risk factor. A retrospective analysis of patients (=1764) hospitalized in Italy showed a higher mortality (HR 1.58, 95%CI 1.30–1.91, adjusted for age and multi-comorbidities) in males only after the age of 65 (the rate is twice as high in the 65–79-year age group and 1.5-fold higher in those aged over 80). The higher mortality of men is mostly evident among those aged over 65 years, long after the average age of menopause.

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KW - COVID-19

KW - Estrogens

KW - Gender

KW - Menopause

KW - SARS-Cov-2

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JO - Maturitas

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Men with COVID-19 die. Women survive

Abstract

Keywords

ASJC Scopus subject areas

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