Melkersson⁻Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature

Salvatore Savasta, Alessandra Rossi, Thomas Foiadelli, Amelia Licari, Anna Maria Elena Perini, Giovanni Farello, Alberto Verrotti, Gian Luigi Marseglia

Research output: Contribution to journalArticlepeer-review


Melkersson-Rosenthal syndrome (MRS) in children is a rare condition, clinically characterised by a triad of synchronous or metachronous symptoms: recurrent peripheral facial palsy, relapsing orofacial oedema, and a fissured tongue; the most recent review published on the topic has reported 30 published patients. The aetiology of this disease is still unclear. However, genetic factors, as well as alterations in immune functions, infections, and allergic reactions have been postulated. We report three children suffering from MRS and perform a literature review of paediatric cases. Taking into account that clinical and laboratoristical criteria for the diagnosis of MRS are lacking, this syndrome is probably underestimated, and we suggest increasing awareness of such a rare syndrome. Close multidisciplinary follow-up of these children with a team composed by paediatricians, neurologists, neuro-ophthalmologists, dermatologists, and otolaryngologists is crucial to guarantee exhaustive management and treatment success, while minimising relapses.

Original languageEnglish
JournalInternational Journal of Environmental Research and Public Health
Issue number7
Publication statusPublished - Apr 10 2019


  • fissured tongue
  • Melkersson Rosenthal Syndrome
  • peripheral facial palsy

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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