Melatonin: Its possible role in the management of viral infections-a brief review

Michela Silvestri, Giovanni A. Rossi

Research output: Contribution to journalArticlepeer-review


Melatonin, a versatile molecule, is synthesized by the pineal gland but also by other organs, including gastrointestinal tract, retina, thymus, bone marrow, and by leukocytes. Besides playing an important role in various functions of the body, including sleep and circadian rhythm regulation, melatonin also shows immunoregulatory, free radical scavenger and antioxidant functions. Because of these latter characteristics melatonin has also been found to be effective in fighting viral infections in a variety of experimental animal and in vitro studies. These data suggest a possible therapeutic potential of melatonin in human virus-induced disorders.

Original languageEnglish
Article number61
JournalItalian Journal of Pediatrics
Issue number1
Publication statusPublished - 2013


  • Antioxidant
  • Encephalitis viruses
  • Inflammation
  • Respiratory syncytial virus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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