TY - JOUR
T1 - Melatonin
T2 - Its possible role in the management of viral infections-a brief review
AU - Silvestri, Michela
AU - Rossi, Giovanni A.
PY - 2013
Y1 - 2013
N2 - Melatonin, a versatile molecule, is synthesized by the pineal gland but also by other organs, including gastrointestinal tract, retina, thymus, bone marrow, and by leukocytes. Besides playing an important role in various functions of the body, including sleep and circadian rhythm regulation, melatonin also shows immunoregulatory, free radical scavenger and antioxidant functions. Because of these latter characteristics melatonin has also been found to be effective in fighting viral infections in a variety of experimental animal and in vitro studies. These data suggest a possible therapeutic potential of melatonin in human virus-induced disorders.
AB - Melatonin, a versatile molecule, is synthesized by the pineal gland but also by other organs, including gastrointestinal tract, retina, thymus, bone marrow, and by leukocytes. Besides playing an important role in various functions of the body, including sleep and circadian rhythm regulation, melatonin also shows immunoregulatory, free radical scavenger and antioxidant functions. Because of these latter characteristics melatonin has also been found to be effective in fighting viral infections in a variety of experimental animal and in vitro studies. These data suggest a possible therapeutic potential of melatonin in human virus-induced disorders.
KW - Antioxidant
KW - Encephalitis viruses
KW - Inflammation
KW - Respiratory syncytial virus
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U2 - 10.1186/1824-7288-39-61
DO - 10.1186/1824-7288-39-61
M3 - Article
C2 - 24090288
AN - SCOPUS:84884878172
SN - 1720-8424
VL - 39
JO - Italian Journal of Pediatrics
JF - Italian Journal of Pediatrics
IS - 1
M1 - 61
ER -