TY - JOUR
T1 - Mechanisms of systemic vasculitis
AU - Manfredi, Angelo A.
AU - Sabbadini, Maria Grazia
AU - Ferri, Luca
AU - Bianchi, Marco E.
AU - Rovere-Querini, Patrizia
PY - 2004/12
Y1 - 2004/12
N2 - Vasculitides comprise a heterogeneous group of disorders, characterized by the chronic inflammation of arteries and veins of different distribution and size. The infiltration of leukocytes is a common feature. We propose that in vasculitis patients environmental and/or inherited factors interfere with the homeostatic response to dying cells. This attracts and activates inflammatory leukocytes in the wall of blood vessels, transforming the initial vascular damage in a self-sustaining process, with eventual clinically overt disease.
AB - Vasculitides comprise a heterogeneous group of disorders, characterized by the chronic inflammation of arteries and veins of different distribution and size. The infiltration of leukocytes is a common feature. We propose that in vasculitis patients environmental and/or inherited factors interfere with the homeostatic response to dying cells. This attracts and activates inflammatory leukocytes in the wall of blood vessels, transforming the initial vascular damage in a self-sustaining process, with eventual clinically overt disease.
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U2 - 10.1016/j.ddmec.2004.11.010
DO - 10.1016/j.ddmec.2004.11.010
M3 - Article
AN - SCOPUS:23744504994
SN - 1740-6765
VL - 1
SP - 297
EP - 302
JO - Drug Discovery Today: Disease Mechanisms
JF - Drug Discovery Today: Disease Mechanisms
IS - 3
ER -