Mechanisms of systemic vasculitis

Angelo A. Manfredi, Maria Grazia Sabbadini, Luca Ferri, Marco E. Bianchi, Patrizia Rovere-Querini

Research output: Contribution to journalArticlepeer-review


Vasculitides comprise a heterogeneous group of disorders, characterized by the chronic inflammation of arteries and veins of different distribution and size. The infiltration of leukocytes is a common feature. We propose that in vasculitis patients environmental and/or inherited factors interfere with the homeostatic response to dying cells. This attracts and activates inflammatory leukocytes in the wall of blood vessels, transforming the initial vascular damage in a self-sustaining process, with eventual clinically overt disease.

Original languageEnglish
Pages (from-to)297-302
Number of pages6
JournalDrug Discovery Today: Disease Mechanisms
Issue number3
Publication statusPublished - Dec 2004

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine


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