Mechanisms for reduced pulmonary diffusing capacity in haematopoietic stem-cell transplantation recipients

Giovanni Barisione; Andrea Bacigalupo; Claudia Brusasco; Chiara Scanarotti; Susanna Penco; Anna Maria Bassi; Teresa Lamparelli; Alessandro Garlaschi; Riccardo Pellegrino; Vito Brusasco

doi:10.1016/j.resp.2014.01.018

Mechanisms for reduced pulmonary diffusing capacity in haematopoietic stem-cell transplantation recipients

Giovanni Barisione, Andrea Bacigalupo, Claudia Brusasco, Chiara Scanarotti, Susanna Penco, Anna Maria Bassi, Teresa Lamparelli, Alessandro Garlaschi, Riccardo Pellegrino, Vito Brusasco

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Lung diffusing capacity for CO (DL_CO) is compromised in haematopoietic stem-cell transplantation (HSCT) recipients. We derived alveolar-capillary membrane conductance (D_M,CO) and pulmonary capillary volume (V_C) from DL_CO and diffusing capacity for NO (DL_NO). Forty patients were studied before and 6 weeks after HSCT. Before HSCT, DL_NO and DL_CO were significantly lower than in 30 healthy controls. D_M,CO was ~40% lower in patients than in controls (pC did not differ significantly. After HSCT, DL_NO and D_M,CO further decreased, the latter by ~22% from before HSCT (pC did not change significantly. Lung density, serum CRP and reactive oxygen metabolites were significantly increased, with the latter being correlated (R²=0.71, pNO. We conclude that DL_NO and, to a lesser extent, DL_CO are compromised before HSCT mainly due to a D_M,CO reduction. A further reduction of D_M,CO without V_C loss occurs after HSCT, possibly related to development of oedema, or interstitial fibrosis, or both.

Original language	English
Pages (from-to)	54-61
Number of pages	8
Journal	Respiratory Physiology and Neurobiology
Volume	194
Issue number	1
DOIs	https://doi.org/10.1016/j.resp.2014.01.018
Publication status	Published - Apr 1 2014

Keywords

Alveolar-capillary membrane conductance
Carbon monoxide
Lung density
Nitric oxide
Pulmonary capillary volume
Reactive oxygen metabolites

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine
Neuroscience(all)
Medicine(all)

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10.1016/j.resp.2014.01.018

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title = "Mechanisms for reduced pulmonary diffusing capacity in haematopoietic stem-cell transplantation recipients",

abstract = "Lung diffusing capacity for CO (DLCO) is compromised in haematopoietic stem-cell transplantation (HSCT) recipients. We derived alveolar-capillary membrane conductance (DM,CO) and pulmonary capillary volume (VC) from DLCO and diffusing capacity for NO (DLNO). Forty patients were studied before and 6 weeks after HSCT. Before HSCT, DLNO and DLCO were significantly lower than in 30 healthy controls. DM,CO was ~40% lower in patients than in controls (pC did not differ significantly. After HSCT, DLNO and DM,CO further decreased, the latter by ~22% from before HSCT (pC did not change significantly. Lung density, serum CRP and reactive oxygen metabolites were significantly increased, with the latter being correlated (R2=0.71, pNO. We conclude that DLNO and, to a lesser extent, DLCO are compromised before HSCT mainly due to a DM,CO reduction. A further reduction of DM,CO without VC loss occurs after HSCT, possibly related to development of oedema, or interstitial fibrosis, or both.",

keywords = "Alveolar-capillary membrane conductance, Carbon monoxide, Lung density, Nitric oxide, Pulmonary capillary volume, Reactive oxygen metabolites",

author = "Giovanni Barisione and Andrea Bacigalupo and Claudia Brusasco and Chiara Scanarotti and Susanna Penco and Bassi, {Anna Maria} and Teresa Lamparelli and Alessandro Garlaschi and Riccardo Pellegrino and Vito Brusasco",

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AU - Barisione, Giovanni

AU - Bacigalupo, Andrea

AU - Brusasco, Claudia

AU - Scanarotti, Chiara

AU - Penco, Susanna

AU - Bassi, Anna Maria

AU - Lamparelli, Teresa

AU - Garlaschi, Alessandro

AU - Pellegrino, Riccardo

AU - Brusasco, Vito

PY - 2014/4/1

Y1 - 2014/4/1

N2 - Lung diffusing capacity for CO (DLCO) is compromised in haematopoietic stem-cell transplantation (HSCT) recipients. We derived alveolar-capillary membrane conductance (DM,CO) and pulmonary capillary volume (VC) from DLCO and diffusing capacity for NO (DLNO). Forty patients were studied before and 6 weeks after HSCT. Before HSCT, DLNO and DLCO were significantly lower than in 30 healthy controls. DM,CO was ~40% lower in patients than in controls (pC did not differ significantly. After HSCT, DLNO and DM,CO further decreased, the latter by ~22% from before HSCT (pC did not change significantly. Lung density, serum CRP and reactive oxygen metabolites were significantly increased, with the latter being correlated (R2=0.71, pNO. We conclude that DLNO and, to a lesser extent, DLCO are compromised before HSCT mainly due to a DM,CO reduction. A further reduction of DM,CO without VC loss occurs after HSCT, possibly related to development of oedema, or interstitial fibrosis, or both.

AB - Lung diffusing capacity for CO (DLCO) is compromised in haematopoietic stem-cell transplantation (HSCT) recipients. We derived alveolar-capillary membrane conductance (DM,CO) and pulmonary capillary volume (VC) from DLCO and diffusing capacity for NO (DLNO). Forty patients were studied before and 6 weeks after HSCT. Before HSCT, DLNO and DLCO were significantly lower than in 30 healthy controls. DM,CO was ~40% lower in patients than in controls (pC did not differ significantly. After HSCT, DLNO and DM,CO further decreased, the latter by ~22% from before HSCT (pC did not change significantly. Lung density, serum CRP and reactive oxygen metabolites were significantly increased, with the latter being correlated (R2=0.71, pNO. We conclude that DLNO and, to a lesser extent, DLCO are compromised before HSCT mainly due to a DM,CO reduction. A further reduction of DM,CO without VC loss occurs after HSCT, possibly related to development of oedema, or interstitial fibrosis, or both.

KW - Alveolar-capillary membrane conductance

KW - Carbon monoxide

KW - Lung density

KW - Nitric oxide

KW - Pulmonary capillary volume

KW - Reactive oxygen metabolites

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Mechanisms for reduced pulmonary diffusing capacity in haematopoietic stem-cell transplantation recipients

Abstract

Keywords

ASJC Scopus subject areas

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