Mechanisms for reduced pulmonary diffusing capacity in haematopoietic stem-cell transplantation recipients

Giovanni Barisione, Andrea Bacigalupo, Claudia Brusasco, Chiara Scanarotti, Susanna Penco, Anna Maria Bassi, Teresa Lamparelli, Alessandro Garlaschi, Riccardo Pellegrino, Vito Brusasco

Research output: Contribution to journalArticlepeer-review


Lung diffusing capacity for CO (DLCO) is compromised in haematopoietic stem-cell transplantation (HSCT) recipients. We derived alveolar-capillary membrane conductance (DM,CO) and pulmonary capillary volume (VC) from DLCO and diffusing capacity for NO (DLNO). Forty patients were studied before and 6 weeks after HSCT. Before HSCT, DLNO and DLCO were significantly lower than in 30 healthy controls. DM,CO was ~40% lower in patients than in controls (pC did not differ significantly. After HSCT, DLNO and DM,CO further decreased, the latter by ~22% from before HSCT (pC did not change significantly. Lung density, serum CRP and reactive oxygen metabolites were significantly increased, with the latter being correlated (R2=0.71, pNO. We conclude that DLNO and, to a lesser extent, DLCO are compromised before HSCT mainly due to a DM,CO reduction. A further reduction of DM,CO without VC loss occurs after HSCT, possibly related to development of oedema, or interstitial fibrosis, or both.

Original languageEnglish
Pages (from-to)54-61
Number of pages8
JournalRespiratory Physiology and Neurobiology
Issue number1
Publication statusPublished - Apr 1 2014


  • Alveolar-capillary membrane conductance
  • Carbon monoxide
  • Lung density
  • Nitric oxide
  • Pulmonary capillary volume
  • Reactive oxygen metabolites

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)
  • Medicine(all)


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