MBL2 genetic polymorphisms in Italian children with adenotonsillar hypertrophy

Domenico Leonardo Grasso; Veronica Ileana Guerci; Elisabetta Zocconi; Michele Milanese; Ludovica Segat; Sergio Crovella

doi:10.1016/j.ijporl.2007.02.015

MBL2 genetic polymorphisms in Italian children with adenotonsillar hypertrophy

Domenico Leonardo Grasso, Veronica Ileana Guerci, Elisabetta Zocconi, Michele Milanese, Ludovica Segat, Sergio Crovella

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the role of the polymorphisms in the first exon of MBL2 gene in the susceptibility to recurrent tonsillitis in a selected group of Italian children and healthy controls. Significant difference has been observed in MBL2 genotype and allelic frequencies between children with recurrent tonsillitis and healthy controls matched for sex and age. Children characterized by a "low MBL" producer genotype, namely 00, are more prone to recurrent tonsillitis when compared to the healthy controls. To our knowledge this is the first report on the role of MBL2 polymorphisms in adenotonsillar hypertrophy and our results shown that presence of MBL2 00 genotype could be used as a prognostic marker in subjects with adenotonsillar hypertrophy.

Original language	English
Pages (from-to)	1013-1016
Number of pages	4
Journal	International Journal of Pediatric Otorhinolaryngology
Volume	71
Issue number	7
DOIs	https://doi.org/10.1016/j.ijporl.2007.02.015
Publication status	Published - Jul 2007

Keywords

Innate immune system
MBL
Tonsillitis

ASJC Scopus subject areas

Otorhinolaryngology
Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine
Surgery

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10.1016/j.ijporl.2007.02.015

Cite this

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title = "MBL2 genetic polymorphisms in Italian children with adenotonsillar hypertrophy",

abstract = "We investigated the role of the polymorphisms in the first exon of MBL2 gene in the susceptibility to recurrent tonsillitis in a selected group of Italian children and healthy controls. Significant difference has been observed in MBL2 genotype and allelic frequencies between children with recurrent tonsillitis and healthy controls matched for sex and age. Children characterized by a {"}low MBL{"} producer genotype, namely 00, are more prone to recurrent tonsillitis when compared to the healthy controls. To our knowledge this is the first report on the role of MBL2 polymorphisms in adenotonsillar hypertrophy and our results shown that presence of MBL2 00 genotype could be used as a prognostic marker in subjects with adenotonsillar hypertrophy.",

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AU - Grasso, Domenico Leonardo

AU - Guerci, Veronica Ileana

AU - Zocconi, Elisabetta

AU - Milanese, Michele

AU - Segat, Ludovica

AU - Crovella, Sergio

PY - 2007/7

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N2 - We investigated the role of the polymorphisms in the first exon of MBL2 gene in the susceptibility to recurrent tonsillitis in a selected group of Italian children and healthy controls. Significant difference has been observed in MBL2 genotype and allelic frequencies between children with recurrent tonsillitis and healthy controls matched for sex and age. Children characterized by a "low MBL" producer genotype, namely 00, are more prone to recurrent tonsillitis when compared to the healthy controls. To our knowledge this is the first report on the role of MBL2 polymorphisms in adenotonsillar hypertrophy and our results shown that presence of MBL2 00 genotype could be used as a prognostic marker in subjects with adenotonsillar hypertrophy.

AB - We investigated the role of the polymorphisms in the first exon of MBL2 gene in the susceptibility to recurrent tonsillitis in a selected group of Italian children and healthy controls. Significant difference has been observed in MBL2 genotype and allelic frequencies between children with recurrent tonsillitis and healthy controls matched for sex and age. Children characterized by a "low MBL" producer genotype, namely 00, are more prone to recurrent tonsillitis when compared to the healthy controls. To our knowledge this is the first report on the role of MBL2 polymorphisms in adenotonsillar hypertrophy and our results shown that presence of MBL2 00 genotype could be used as a prognostic marker in subjects with adenotonsillar hypertrophy.

KW - Innate immune system

KW - MBL

KW - Tonsillitis

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MBL2 genetic polymorphisms in Italian children with adenotonsillar hypertrophy

Abstract

Keywords

ASJC Scopus subject areas

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