Marked improvement in cardiovascular function after successful transsphenoidal surgery in acromegalic patients

Giuseppe Minniti, Carlo Moroni, Marie Lise Jaffrain-Rea, Vincenzo Esposito, Antonio Santoro, Cesare Affricano, Giampaolo Cantore, Guido Tamburrano, Rosario Cassone

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OBJECTIVE: Transsphenoidal surgery results in biochemical remission of acromegaly in 45-80% of patients; however, few studies have addressed the impact of transsphenoidal surgery on cardiovascular function in acromegalic patients. The aim of this prospective study was to investigate the effects of postoperative GH/IGF-I normalization on echocardio-graphic parameters and blood pressure (BP) in a series of patients with active acromegaly. DESIGN: An open prospective study. PATIENTS: Thirty newly diagnosed acromegalic patients undergoing transsphenoidal surgery. MEASUREMENTS: Doppler echocardiography and 24-h ambulatory blood pressure monitoring were performed before and 6 months after transsphenoidal surgery. RESULTS: Fifteen patients were considered to be well controlled postoperatively (group A), as defined by normal age-corrected IGF-I levels and glucose-suppressed GH levels less than 2 mU/l, the remaining 15 patients being considered as poorly controlled (group B). In group A, a postoperative decrease of left ventricular mass index was observed (104.4 ± 6.6 vs. 127.1 ± 7.7 g/m2; P <0.001), associated with an improvement of some indices of diastolic function, such as an increase of the early/late transmitral peak flow velocity (P <0.05) and a decrease of isovolumic relaxation time (P <0.01). No significant change was observed in group B. A significant decrease of 24-h systolic BP was also observed in group A (P <0.05) and five of six patients normalized their BP circadian rythm. In contrast, a nonsignificant increase in BP values, with a persistent blunted BP profile where present, was observed in group B. CONCLUSIONS: We conclude that successful transsphenoidal surgery is able to induce a significant improvement in some cardiac parameters and a slight reduction in systolic blood pressure in acromegalic patients.

Original languageEnglish
Pages (from-to)307-313
Number of pages7
JournalClinical Endocrinology
Issue number3
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Endocrinology


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