Margin assessment in soft tissue sarcomas: Review of the literature

Andrea Sambri, Emilia Caldari, Michele Fiore, Riccardo Zucchini, Claudio Giannini, Maria Giulia Pirini, Paolo Spinnato, Alberta Cappelli, Davide Maria Donati, Massimiliano De Paolis

Research output: Contribution to journalReview articlepeer-review


Adequacy of margins must take into consideration both the resection margin width (quantity) and anatomic barrier (quality). There are several classification schemes for reporting surgical resection margin status for soft tissue sarcomas (STS). Most of the studies regarding treatment outcomes in STS included all histologic grades and histological subtypes, which include infiltrative and non‐infiltrative subtypes and are very heterogeneous in terms of both histologic characteristics and treatment modalities (adjuvant treatments or not). This lack of consistency makes it difficult to compare results from study to study. Therefore, there is a great need for evidence‐based standardization concerning the width of resection margins. The aim of this narrative review is to provide a comprehensive assessment of the literature on margins, and to highlight the need for a uniform description of the margin status for patients with STS. Patient cases should be discussed at multidisciplinary tumor boards and treatments should be individualized to clinical and demographic characteristics, which must include also a deep knowledge of specific histotypes behaviors, particularly infiltrative ones.

Original languageEnglish
Article number1687
Pages (from-to)1-16
Number of pages16
Issue number7
Publication statusPublished - Apr 1 2021


  • Classification
  • Infiltrative
  • Local recurrence
  • Margins
  • Soft tissue sarcoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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