Magnitude and determinants of CD4 recovery after haart resumption after 1 cycle of treatment interruption

Cristina Mussini, Giota Touloumi, Giorgos Bakoyannis, Caroline Sabin, Antonella Castagna, Laura Sighinolfi, Lars E. Erikson, Goran Bratt, Vanni Borghi, Adriano Lazzarin, Andrea Cossarizza, Roberto Esposito

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: The extent of immune reconstitution following HAART resumption after 1 cycle of treatment interruption (TI) is not well known. METHODS: Multicenter retrospective analysis of patients who discontinued HAART with a CD4 > 500 cells/μL. Cox proportional hazards models were used to identify prognostic factors for immunologic response after treatment resumption. CD4 trends were investigated using linear mixed models. RESULTS: One hundred and eighty-three individuals were included. Median CD4 at TI and at treatment restart were 748 and 459 cells/μL, respectively. Median time from TI to treatment restart was 5.52 months. Ninety percent of the patients reached an undetectable viral load. One hundred and twenty-five subjects experienced immunologic response; 66 patients reached their pre-TI CD4 levels. At 3, 6, 12, and 24 months after treatment restart, the median CD4 increase was 149, 153, 161, and 178 cells/μL, respectively. Subjects with less steep CD4 declines during TI tended to have a lower initial CD4 increase, as did those reinitiating HAART with viral loads

Original languageEnglish
Pages (from-to)588-594
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number5
Publication statusPublished - Dec 2009


  • HAART resumption
  • HIV infection
  • Immunological response
  • Prognostic factors
  • Treatment interruption
  • Virologic response

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Medicine(all)


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