Magnetic resonance evaluation of autonomous thyroid nodules treated by percutaneous ethanol injection

F. Sardanelli, G. D. Giordano, E. Melani, R. C. Parodi, M. Giusti, G. Garlaschi

Research output: Contribution to journalArticlepeer-review


Magnetic resonance (MR) imaging was used to evaluate the effect of ultrasound-guided percutaneous ethanol injection (PEI) of autonomous thyroid nodules (ATNs). Nine patients affected with ATN (3.7-32.2 mL volume) underwent PEI (4-19 mL ethanol, subdivided in 3-6 weekly procedures). MR imaging (1.5 T) was performed before each alcoholization and 1 month after the last PEI procedure with the following parameters: T1- (550/12) and T2- weighted (2200/160) spin-echo images; 4-mm slices, 10% gap; coronal planes. A further seven patients with normal thyroid function, who had undergone PEI 6- 18 months before, underwent an MR examination with the same parameters. The signal-to-noise ratio (S/N) of ATN and extranodular gland, as well as ATN volume, were evaluated on the T2-weighted images. On T1-weighted images, ATNs appeared mostly hypointense before treatment, with hyperintense areas during treatment, and were lightly hyperintense 6-18 months after treatment. S/N on T2-weighted images: extranodular gland 3.5-9.2; ATNs, before treatment 13.2-19.7, before the last procedure 7.7-11.6, 1 month after the last procedure 5.6-10.9; previously treated ATNs, 4.3-8.2. No significant volume reduction was observed with MR 1 month after the last procedure. The MR examination time was about 15 minutes. In conclusion, the effect of PEI on ATNs can be evaluated with an MR examination that is not very time consuming.

Original languageEnglish
Pages (from-to)267-274
Number of pages8
JournalMagnetic Resonance Materials in Physics, Biology, and Medicine
Issue number4
Publication statusPublished - 1997


  • Autonomous nodules
  • Hyperthyroidism
  • Magnetic resonance
  • Percutaneous ethanol injection
  • Thyroid
  • Thyroid nodules

ASJC Scopus subject areas

  • Biophysics
  • Genetics


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