TY - JOUR
T1 - Lymphoproliferative response in primary human cytomegalovirus (HCMV) infection is delayed in HCMV transmitter mothers
AU - Revello, Maria Grazia
AU - Lilleri, Daniele
AU - Zavattoni, Maurizio
AU - Furione, Milena
AU - Genini, Emilia
AU - Comolli, Giuditta
AU - Gerna, Giuseppe
PY - 2006/1/15
Y1 - 2006/1/15
N2 - Background. The T cell-mediated immune response to human cytomegalovirus (HCMV) after primary infection, as well as the determinants of intrauterine transmission, are poorly understood. Methods. Sequential peripheral blood leukocyte samples from 74 pregnant women and 29 nonpregnant individuals with primary infection were examined for HCMV-specific CD4+ T cells by cytokine flow cytometry (CFC) and lymphoproliferative response (LPR) analysis. Immunological results for 19 transmitter and 21 non-transmitter mothers were compared. Results. Comparison of CFC and LPR analysis results showed that (1) there was no difference between pregnant and nonpregnant individuals; (2) HCMV-specific CD4+ T cells were detected by CFC, in the absence of an LPR to HCMV, in the great majority or the totality (according to different intervals) of samples collected from both pregnant and nonpregnant individuals during follow-up; and (3) LPR to HCMV was significantly (P
AB - Background. The T cell-mediated immune response to human cytomegalovirus (HCMV) after primary infection, as well as the determinants of intrauterine transmission, are poorly understood. Methods. Sequential peripheral blood leukocyte samples from 74 pregnant women and 29 nonpregnant individuals with primary infection were examined for HCMV-specific CD4+ T cells by cytokine flow cytometry (CFC) and lymphoproliferative response (LPR) analysis. Immunological results for 19 transmitter and 21 non-transmitter mothers were compared. Results. Comparison of CFC and LPR analysis results showed that (1) there was no difference between pregnant and nonpregnant individuals; (2) HCMV-specific CD4+ T cells were detected by CFC, in the absence of an LPR to HCMV, in the great majority or the totality (according to different intervals) of samples collected from both pregnant and nonpregnant individuals during follow-up; and (3) LPR to HCMV was significantly (P
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U2 - 10.1086/498872
DO - 10.1086/498872
M3 - Article
C2 - 16362891
AN - SCOPUS:30944438250
SN - 0022-1899
VL - 193
SP - 269
EP - 276
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -