Lung volumes and distribution of ventilation in survivors to Congenital Diaphragmatic Hernia (CDH) during infancy

Andrea Dotta, Sabrina Palamides, Annabella Braguglia, Francesco Crescenzi, Maria Paola Ronchetti, Flaminia Calzolari, Barbara Daniela Iacobelli, Pietro Bagolan, Carlo Corchia, Marcello Orzalesi

Research output: Contribution to journalArticlepeer-review


The assessment of lung volumes, particularly functional residual capacity (FRC), is crucial for understanding lung development during infancy in CDH patients. Aim: To evaluate changes in lung function during infancy in subjects with CDH treated with a "gentle ventilation" technique and delayed surgery strategy in the neonatal period. Methods: 13 CDH infants were studied twice and compared with a population of 28 healthy infants (HI). Tidal-Volume (Vt), respiratory rate (RR) and time to peak expiratory flow/expiratory time ratio (tPTEF/Te) were measured with an ultrasonic flow meter; Compliance (Crs) and Resistance (Rrs) of the respiratory system were studied with the single occlusion technique; FRC and Lung Clearance Index (LCI), were assessed with the sulfur hexafluoride (SF6) wash-in/wash-out technique. The differences between the first (T1) and second (T2) measurement in the CDH group were assessed by the Student's t-test for paired values. For each set of measurement (T1 and T2) the values were compared with HI by Student's Mest. Results: Mean age at test was 7.5 ± 5.2 months for HI, 4.5 ± 2.5 at T1 and 11.9 ± 4.5 months at T2 for CDH infants. At T1 there were no significant differences between CDH infants and HI in Vt, Crs, and FRC, while tPTEF/te ratio was lower and RR, Rrs, and LCI were higher in CDH patients than in HI. At T2 Vt, Crs, and FRC remained normal in CDH patients as well as RR that, at this time was not different between CDH and healthy infants; tPTEF/te remained below and Rrs and LCI remained above normal ranges, indicating a persistent impairment in lower airways patency. Conclusions: Lung function in infants with severe CDH is characterized by a persistent impairment in airways patency and significant inhomogeneity of ventilation, suggesting a peripheral bronchial obstruction even if the other lung function tests are within normal ranges.

Original languageEnglish
Pages (from-to)600-604
Number of pages5
JournalPediatric Pulmonology
Issue number7
Publication statusPublished - Jul 2007


  • Congenital diaphragmatic hernia
  • Functional residual capacity
  • Lung clearance index

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine


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