Low prevalence of colorectal neoplasia in microscopic colitis: A large prospective multi-center study

Edoardo Borsotti, Brigida Barberio, Renata D'Incà, Gianluca Bonitta, Flaminia Cavallaro, Luisa Spina, Luca Pastorelli, Emanuele Rondonotti, Leonardo Samperi, Marco Dinelli, Maurizio Vecchi, Gian Eugenio Tontini

Research output: Contribution to journalArticlepeer-review


Background and Aims: Microscopic colitis (MC) is the most frequent condition in subjects undergoing ileocolonoscopy for chronic non-bloody diarrhea (CNBD) in Western countries. Emerging evidence has shown a negative association between MC and colorectal cancer. Within this prospective multi-center study we have evaluated the risk of colorectal neoplasia in MC and non-MC patients with CNBD receiving ileocolonoscopy with high-definition plus virtual chromoendoscopic imaging and histopathological assessment. Methods: Patients with CNBD of unknown origin were prospectively enrolled in 5 referral centers in Northern Italy for ileocolonoscopy with high-definition and digital/optical chromoendoscopy plus multiple biopsies in each segment. The prevalence of colorectal neoplasia (cancer, adenoma, serrated lesion) in MC was compared to that observed in a control group including CNBD patients negative for MC, inflammatory bowel disease or eosinophilic colitis. Results: From 2014 and 2017, 546 consecutive CNBD patients were recruited. Among the 492 patients (mean age 53±18 years) fulfilling the inclusion criteria against the exclusion critieria, MC was the predominant diagnosis at histopathological assessment (8.7%: N=43, 28 CC, 15 LC). The regression model adjusted for age and gender showed a significant negative association between the diagnosis of CM and colorectal neoplasia (OR=0.39; 95% CI 0.22−0.67, p <0.001) with a 60% decreased risk of adenomatous and neoplastic serrated polyps as compared to the control group (n=412). Conclusion: This multi-center study confirms MC as a low-risk condition for colorectal neoplasia. No surveillance colonoscopy program is to be performed for MC diagnosis.

Original languageEnglish
Pages (from-to)846-851
JournalDigestive and Liver Disease
Issue number7
Publication statusPublished - 2021


  • Advanced endoscopic imaging
  • Chronic non-bloody diarrhea
  • Collagenous colitis
  • Colorectal adenoma
  • Colorectal cancer
  • Lymphocytic colitis
  • Microscopic colitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'Low prevalence of colorectal neoplasia in microscopic colitis: A large prospective multi-center study'. Together they form a unique fingerprint.

Cite this