Low-grade endotoxemia and clotting activation in the early phase of pneumonia

Roberto Cangemi; Patrizia Della Valle; Camilla Calvieri; Gloria Taliani; Patrizia Ferroni; Marco Falcone; Roberto Carnevale; Simona Bartimoccia; Armando D'angelo; Francesco Violi

doi:10.1111/resp.12854

Low-grade endotoxemia and clotting activation in the early phase of pneumonia

Roberto Cangemi, Patrizia Della Valle, Camilla Calvieri, Gloria Taliani, Patrizia Ferroni, Marco Falcone, Roberto Carnevale, Simona Bartimoccia, Armando D'angelo, Francesco Violi

Research output: Contribution to journal › Article › peer-review

Abstract

Background and objective: Community-acquired pneumonia (CAP) is associated with an increased risk of arterial and venous thrombosis but the underlying pathophysiological mechanisms are still unclear. We investigated if, in patients with CAP, a pro-thrombotic state does exist and its relationship with serum levels of endotoxins. Methods: A total of 104 consecutive patients with CAP were prospectively recruited and followed up until discharge. At admission and at discharge, serum endotoxins, systemic markers of clotting activation and zonulin, a marker of gut permeability, were analysed. Hospitalized patients matched for gender, age and comorbidities but without infections were used as control. Results: At admission, CAP patients showed higher plasma levels of F₁ ₊₂, a marker of thrombin generation (P=0.023), and lower levels of protein C (PC; P1 ₊₂ significantly decreased (P

Original language	English
Journal	Respirology
DOIs	https://doi.org/10.1111/resp.12854
Publication status	Accepted/In press - 2016

Keywords

Endotoxin
Pneumonia
Protein C
Thrombosis
Zonulin

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1111/resp.12854

Cite this

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title = "Low-grade endotoxemia and clotting activation in the early phase of pneumonia",

abstract = "Background and objective: Community-acquired pneumonia (CAP) is associated with an increased risk of arterial and venous thrombosis but the underlying pathophysiological mechanisms are still unclear. We investigated if, in patients with CAP, a pro-thrombotic state does exist and its relationship with serum levels of endotoxins. Methods: A total of 104 consecutive patients with CAP were prospectively recruited and followed up until discharge. At admission and at discharge, serum endotoxins, systemic markers of clotting activation and zonulin, a marker of gut permeability, were analysed. Hospitalized patients matched for gender, age and comorbidities but without infections were used as control. Results: At admission, CAP patients showed higher plasma levels of F1 +2, a marker of thrombin generation (P=0.023), and lower levels of protein C (PC; P1 +2 significantly decreased (P",

keywords = "Endotoxin, Pneumonia, Protein C, Thrombosis, Zonulin",

author = "Roberto Cangemi and {Della Valle}, Patrizia and Camilla Calvieri and Gloria Taliani and Patrizia Ferroni and Marco Falcone and Roberto Carnevale and Simona Bartimoccia and Armando D'angelo and Francesco Violi",

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T1 - Low-grade endotoxemia and clotting activation in the early phase of pneumonia

AU - Cangemi, Roberto

AU - Della Valle, Patrizia

AU - Calvieri, Camilla

AU - Taliani, Gloria

AU - Ferroni, Patrizia

AU - Falcone, Marco

AU - Carnevale, Roberto

AU - Bartimoccia, Simona

AU - D'angelo, Armando

AU - Violi, Francesco

PY - 2016

Y1 - 2016

N2 - Background and objective: Community-acquired pneumonia (CAP) is associated with an increased risk of arterial and venous thrombosis but the underlying pathophysiological mechanisms are still unclear. We investigated if, in patients with CAP, a pro-thrombotic state does exist and its relationship with serum levels of endotoxins. Methods: A total of 104 consecutive patients with CAP were prospectively recruited and followed up until discharge. At admission and at discharge, serum endotoxins, systemic markers of clotting activation and zonulin, a marker of gut permeability, were analysed. Hospitalized patients matched for gender, age and comorbidities but without infections were used as control. Results: At admission, CAP patients showed higher plasma levels of F1 +2, a marker of thrombin generation (P=0.023), and lower levels of protein C (PC; P1 +2 significantly decreased (P

AB - Background and objective: Community-acquired pneumonia (CAP) is associated with an increased risk of arterial and venous thrombosis but the underlying pathophysiological mechanisms are still unclear. We investigated if, in patients with CAP, a pro-thrombotic state does exist and its relationship with serum levels of endotoxins. Methods: A total of 104 consecutive patients with CAP were prospectively recruited and followed up until discharge. At admission and at discharge, serum endotoxins, systemic markers of clotting activation and zonulin, a marker of gut permeability, were analysed. Hospitalized patients matched for gender, age and comorbidities but without infections were used as control. Results: At admission, CAP patients showed higher plasma levels of F1 +2, a marker of thrombin generation (P=0.023), and lower levels of protein C (PC; P1 +2 significantly decreased (P

KW - Endotoxin

KW - Pneumonia

KW - Protein C

KW - Thrombosis

KW - Zonulin

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DO - 10.1111/resp.12854

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ER -

Low-grade endotoxemia and clotting activation in the early phase of pneumonia

Abstract

Keywords

ASJC Scopus subject areas

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