TY - JOUR
T1 - Low birth weight for gestational age associates with reduced glucose concentrations at birth, infancy and childhood
AU - Ghirri, Paolo
AU - Ladaki, Christini
AU - Bartoli, Ambra
AU - Scirè, Giuseppe
AU - Vuerich, Marco
AU - Spadoni, Gian Luigi
AU - Maiorana, Arianna
AU - Geremia, Caterina
AU - Boldrini, Antonio
AU - Cianfarani, Stefano
PY - 2007/3
Y1 - 2007/3
N2 - Background/Aims: Our aim was to investigate glucose homeostasis, insulin sensitivity and insulin-like growth factor (IGF) system status in children born small for gestational age (SGA). Methods: A case-control study was carried out at birth, infancy and childhood, comparing SGA with children appropriate for gestational age strictly matched for age, gender, pubertal status and body mass index. Ninety newborns, 52 infants, and 68 children were studied. Fasting insulin (I
F), fasting glucose (G
F) to I
F ratio (G
F/I
F), the homeostasis model assessment of insulin sensitivity, the quantitative insulin sensitivity check index, insulinogenic index and the triglyceride/high-density lipoprotein-cholesterol ratio were measured. IGF-I, IGF-binding protein-3 and the IGF-I/IGF-binding protein-3 molar ratio were assessed. Results: Glucose concentrations were lower in SGA newborns (p <0.0001), infants (p = 0.01), and children (p = 0.001). Birth weight correlated with glucose levels at birth (r = 0.59, p <0.0001), 12 months (r = 0.29, p = 0.04) and childhood (r = 0.44, p <0.0001). Conclusion: Our results provide evidence for a developmental adaptation of glucose metabolism in SGA children leading to reduced glucose concentrations.
AB - Background/Aims: Our aim was to investigate glucose homeostasis, insulin sensitivity and insulin-like growth factor (IGF) system status in children born small for gestational age (SGA). Methods: A case-control study was carried out at birth, infancy and childhood, comparing SGA with children appropriate for gestational age strictly matched for age, gender, pubertal status and body mass index. Ninety newborns, 52 infants, and 68 children were studied. Fasting insulin (I
F), fasting glucose (G
F) to I
F ratio (G
F/I
F), the homeostasis model assessment of insulin sensitivity, the quantitative insulin sensitivity check index, insulinogenic index and the triglyceride/high-density lipoprotein-cholesterol ratio were measured. IGF-I, IGF-binding protein-3 and the IGF-I/IGF-binding protein-3 molar ratio were assessed. Results: Glucose concentrations were lower in SGA newborns (p <0.0001), infants (p = 0.01), and children (p = 0.001). Birth weight correlated with glucose levels at birth (r = 0.59, p <0.0001), 12 months (r = 0.29, p = 0.04) and childhood (r = 0.44, p <0.0001). Conclusion: Our results provide evidence for a developmental adaptation of glucose metabolism in SGA children leading to reduced glucose concentrations.
KW - Glucose concentration
KW - Insulin sensitivity
KW - Insulin-like growth factor system
KW - Intrauterine growth restriction
KW - Low birth weight
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U2 - 10.1159/000096582
DO - 10.1159/000096582
M3 - Article
C2 - 17065818
AN - SCOPUS:33847648365
SN - 0301-0163
VL - 67
SP - 123
EP - 131
JO - Hormone Research
JF - Hormone Research
IS - 3
ER -