Loss of Swallow Tail Sign on Susceptibility-Weighted Imaging in Dementia with Lewy Bodies

Giovanni Rizzo; Roberto De Blasi; Rosa Capozzo; Rosanna Tortelli; Maria Rosaria Barulli; Rocco Liguori; Daniela Grasso; Giancarlo Logroscino

doi:10.3233/JAD-180687

Loss of Swallow Tail Sign on Susceptibility-Weighted Imaging in Dementia with Lewy Bodies

Giovanni Rizzo, Roberto De Blasi, Rosa Capozzo, Rosanna Tortelli, Maria Rosaria Barulli, Rocco Liguori, Daniela Grasso, Giancarlo Logroscino

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

We assessed nigral dorsolateral hyperintensity (swallow tail sign) at susceptibility-weighted imaging using 3T-MRI in 15 dementia with Lewy bodies (DLB), 11 Alzheimer's disease (AD), and 8 frontotemporal dementia (FTD) patients and 10 subjects with subjective memory complaint (SMC). More DLB patients lacked nigral hyperintesity (p<0.05). Sensitivity, specificity, and accuracy of DLB diagnosis were, respectively: 80, 64, and 73 versus AD; 80, 75, and 78 versus FTD; and 80, 90, and 84 versus SMC. Considering bilateral loss, sensitivity decreased (53) but specificity increased (82-100). Swallow tail sign loss, especially if bilateral, can be useful for DLB diagnosis.

Original language	English
Pages (from-to)	61-65
Number of pages	5
Journal	Journal of Alzheimer's Disease
Volume	67
Issue number	1
DOIs	https://doi.org/10.3233/JAD-180687
Publication status	Published - Jan 1 2019

Keywords

Dementia with Lewy bodies
magnetic resonance imaging
nigrosome
susceptibility-weighted imaging
swallow tail sign

ASJC Scopus subject areas

Neuroscience(all)
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.3233/JAD-180687

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title = "Loss of Swallow Tail Sign on Susceptibility-Weighted Imaging in Dementia with Lewy Bodies",

abstract = "We assessed nigral dorsolateral hyperintensity (swallow tail sign) at susceptibility-weighted imaging using 3T-MRI in 15 dementia with Lewy bodies (DLB), 11 Alzheimer's disease (AD), and 8 frontotemporal dementia (FTD) patients and 10 subjects with subjective memory complaint (SMC). More DLB patients lacked nigral hyperintesity (p<0.05). Sensitivity, specificity, and accuracy of DLB diagnosis were, respectively: 80, 64, and 73 versus AD; 80, 75, and 78 versus FTD; and 80, 90, and 84 versus SMC. Considering bilateral loss, sensitivity decreased (53) but specificity increased (82-100). Swallow tail sign loss, especially if bilateral, can be useful for DLB diagnosis.",

keywords = "Dementia with Lewy bodies, magnetic resonance imaging, nigrosome, susceptibility-weighted imaging, swallow tail sign",

author = "Giovanni Rizzo and {De Blasi}, Roberto and Rosa Capozzo and Rosanna Tortelli and Barulli, {Maria Rosaria} and Rocco Liguori and Daniela Grasso and Giancarlo Logroscino",

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doi = "10.3233/JAD-180687",

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AU - Rizzo, Giovanni

AU - De Blasi, Roberto

AU - Capozzo, Rosa

AU - Tortelli, Rosanna

AU - Barulli, Maria Rosaria

AU - Liguori, Rocco

AU - Grasso, Daniela

AU - Logroscino, Giancarlo

N1 - Ricercatori distaccati presso IRCCS a seguito Convenzione esclusiva con Università di Bologna (Rizzo Giovanni, Liguori Rocco).

PY - 2019/1/1

Y1 - 2019/1/1

N2 - We assessed nigral dorsolateral hyperintensity (swallow tail sign) at susceptibility-weighted imaging using 3T-MRI in 15 dementia with Lewy bodies (DLB), 11 Alzheimer's disease (AD), and 8 frontotemporal dementia (FTD) patients and 10 subjects with subjective memory complaint (SMC). More DLB patients lacked nigral hyperintesity (p<0.05). Sensitivity, specificity, and accuracy of DLB diagnosis were, respectively: 80, 64, and 73 versus AD; 80, 75, and 78 versus FTD; and 80, 90, and 84 versus SMC. Considering bilateral loss, sensitivity decreased (53) but specificity increased (82-100). Swallow tail sign loss, especially if bilateral, can be useful for DLB diagnosis.

AB - We assessed nigral dorsolateral hyperintensity (swallow tail sign) at susceptibility-weighted imaging using 3T-MRI in 15 dementia with Lewy bodies (DLB), 11 Alzheimer's disease (AD), and 8 frontotemporal dementia (FTD) patients and 10 subjects with subjective memory complaint (SMC). More DLB patients lacked nigral hyperintesity (p<0.05). Sensitivity, specificity, and accuracy of DLB diagnosis were, respectively: 80, 64, and 73 versus AD; 80, 75, and 78 versus FTD; and 80, 90, and 84 versus SMC. Considering bilateral loss, sensitivity decreased (53) but specificity increased (82-100). Swallow tail sign loss, especially if bilateral, can be useful for DLB diagnosis.

KW - Dementia with Lewy bodies

KW - magnetic resonance imaging

KW - nigrosome

KW - susceptibility-weighted imaging

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Loss of Swallow Tail Sign on Susceptibility-Weighted Imaging in Dementia with Lewy Bodies

Abstract

Keywords

ASJC Scopus subject areas

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