Lopinavir/ritonavir + tenofovir Dual Therapy versus Lopinavir/ritonavir-Based Triple Therapy in HIV-Infected Antiretroviral Naïve Subjects: The Kalead Study

Mari Pinola; Adriano Lazzarin; Andrea Antinori; Giampiero Carosi; Giovanni Di Perri; Mauro Moroni; Vincenzo Vullo; Giuseppe Pastore; Michael Norton; Umberto di Luzio Paparatti

doi:10.4172/jaa.1000024

Lopinavir/ritonavir + tenofovir Dual Therapy versus Lopinavir/ritonavir-Based Triple Therapy in HIV-Infected Antiretroviral Naïve Subjects: The Kalead Study

Mari Pinola, Adriano Lazzarin, Andrea Antinori, Giampiero Carosi, Giovanni Di Perri, Mauro Moroni, Vincenzo Vullo, Giuseppe Pastore, Michael Norton, Umberto di Luzio Paparatti

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: With reference to the clinical need for simple, potent and safe antiretroviral regimens, Lopinavir/ ritonavir + tenofovir (LPV/r+TDF) two-drug initial regimen was studied for efficacy and safety in HIV-infected patients. Methods: Kalead was a prospective, randomized, open-label, 72-week trial comparing LPV/r+TDF versus LPV/r + two (non-TDF) NRTIs in HIV-infected adults with HIV-RNA >400 copies/mL and any CD4 count. Primary endpoint was the proportion of subjects with HIV-RNA

Original language	English
Pages (from-to)	56-62
Number of pages	7
Journal	Journal of Antivirals and Antiretrovirals
Volume	2
Issue number	4
DOIs	https://doi.org/10.4172/jaa.1000024
Publication status	Published - 2010

Keywords

ARV therapy
Dual therapy
Lopinavir
NRTI
Protease inhibitors
Tenofovir

ASJC Scopus subject areas

Infectious Diseases
Virology

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10.4172/jaa.1000024

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Pinola, M., Lazzarin, A., Antinori, A., Carosi, G., Di Perri, G., Moroni, M., Vullo, V., Pastore, G., Norton, M., & di Luzio Paparatti, U. (2010). Lopinavir/ritonavir + tenofovir Dual Therapy versus Lopinavir/ritonavir-Based Triple Therapy in HIV-Infected Antiretroviral Naïve Subjects: The Kalead Study. Journal of Antivirals and Antiretrovirals, 2(4), 56-62. https://doi.org/10.4172/jaa.1000024

Pinola, M, Lazzarin, A, Antinori, A, Carosi, G, Di Perri, G, Moroni, M, Vullo, V, Pastore, G, Norton, M & di Luzio Paparatti, U 2010, 'Lopinavir/ritonavir + tenofovir Dual Therapy versus Lopinavir/ritonavir-Based Triple Therapy in HIV-Infected Antiretroviral Naïve Subjects: The Kalead Study', Journal of Antivirals and Antiretrovirals, vol. 2, no. 4, pp. 56-62. https://doi.org/10.4172/jaa.1000024

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author = "Mari Pinola and Adriano Lazzarin and Andrea Antinori and Giampiero Carosi and {Di Perri}, Giovanni and Mauro Moroni and Vincenzo Vullo and Giuseppe Pastore and Michael Norton and {di Luzio Paparatti}, Umberto",

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AU - Pinola, Mari

AU - Lazzarin, Adriano

AU - Antinori, Andrea

AU - Carosi, Giampiero

AU - Di Perri, Giovanni

AU - Moroni, Mauro

AU - Vullo, Vincenzo

AU - Pastore, Giuseppe

AU - Norton, Michael

AU - di Luzio Paparatti, Umberto

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Lopinavir/ritonavir + tenofovir Dual Therapy versus Lopinavir/ritonavir-Based Triple Therapy in HIV-Infected Antiretroviral Naïve Subjects: The Kalead Study

Abstract

Keywords

ASJC Scopus subject areas

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