Long-term mortality and incidence of cardiovascular diseases and type 2 diabetes in diabetic and nondiabetic obese patients undergoing gastric banding: A controlled study

Antonio Ettore Maria Pontiroli, Ahmed S. Zakaria, Ermanno Mantegazza, Alberto Morabito, Alessandro Saibene, Enrico Stefano Maria Mozzi, Giancarlo Micheletto, A. Veronelli, Barbara Zecchini, Ahmed Zakaria, Francesca Frigè, Luca Rossetti, A. Benetti, Maurizio Cristina, Michele Paganelli, Paola Vedani, Valerio Ceriani, Maria Grazia Angeletti, Mariangela Autelitano, L. C. D'OroPiergiorgio Berni, Antonio Giampiero Russo

Research output: Contribution to journalArticlepeer-review


Background and aim: Aim of this retrospective study was to compare long-term mortality and incidence of new diseases [diabetes and cardiovascular (CV) disease] in morbidly obese diabetic and nondiabetic patients, undergoing gastric banding (LAGB) in comparison to medical treatment. Patients and methods: Medical records of obese patients [body mass index (BMI) > 35 kg/m2 undergoing LAGB (n = 385; 52 with diabetes) or medical treatment (controls, n = 681; 127 with diabetes), during the period 1995-2001 (visit 1)] were collected. Patients were matched for age, sex, BMI, and blood pressure. Identification codes of patients were entered in the Italian National Health System Lumbardy database, that contains life status, causes of death, as well as exemptions, drug prescriptions, and hospital admissions (proxies of diseases) from visit 1 to September 2012. Survival was compared across LAGB patients and matched controls using Kaplan-Meier plots adjusted Cox regression analyses. Results: Observation period was 13.9 ± 1.87 (mean ± SD). Mortality rate was 2.6, 6.6, and 10.1 % in controls at 5, 10, and 15 years, respectively; mortality rate was 0.8, 2.5, and 3.1 % in LAGB patients at 5, 10, and 15 years, respectively. Compared to controls, surgery was associated with reduced mortality [HR 0.35, 95 % CI 0.19-0.65, p <0.001 at univariate analysis, HR 0.41, 95 % CI 0.21-0.76, p <0.005 at adjusted analysis], similar in diabetic [HR 0.34, 95 % CI 0.13-0.87, p = 0.025] and nondiabetic [HR 0.42, 95 % CI 0.19-0.97, p = 0.041] patients. Surgery was also associated with lower incidence of diabetes (15 vs 48 cases, p = 0.035) and CV diseases (52 vs 124 cases, p = 0.048), and of hospital admissions (88 vs 197, p = 0.04). Conclusion: Up to 17 years, gastric banding is associated with reduced mortality in diabetic and nondiabetic patients, and with reduced incidence of diabetes and cardiovascular diseases.

Original languageEnglish
Article number39
JournalCardiovascular Diabetology
Issue number1
Publication statusPublished - Feb 27 2016


  • Adjustable gastric banding
  • Bariatric surgery
  • Cardiovascular disease
  • Cox proportional hazards model
  • Diabetes mellitus
  • Exemptions
  • Hospital admissions
  • ICD10
  • Kaplan-Meier
  • Mortality
  • Obesity
  • Prevention of cardiovascular disease
  • Prevention of diabetes
  • Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism


Dive into the research topics of 'Long-term mortality and incidence of cardiovascular diseases and type 2 diabetes in diabetic and nondiabetic obese patients undergoing gastric banding: A controlled study'. Together they form a unique fingerprint.

Cite this