Long term memory profile of disorders associated with dysregulation of the RAS-MAPK signaling cascade

Paolo Alfieri, Laura Cesarini, Maria Mallardi, Giorgia Piccini, Cristina Caciolo, Chiara Leoni, Nadia Mirante, Francesca Pantaleoni, Maria Cristina Digilio, Maria Luigia Gambardella, Marco Tartaglia, Stefano Vicari, Eugenio Mercuri, Giuseppe Zampino

Research output: Contribution to journalArticlepeer-review


In the present study we evaluated long term memory in twenty individuals with molecularly confirmed diagnosis of Noonan syndrome and LEOPARD syndrome, two disorders caused by mutations in genes coding transducers participating in the RAS-MAPK signaling cascade. The profile of explicit long term memory abilities was investigated using PROMEA, which includes a battery of tests specifically developed to assess memory and learning in verbal, visual and spatial domains. Ten individuals (50%) had impaired (≤5th percentile) or below average (≤15th percentile) performance on a delayed verbal free recall memory task, four (20%) on a delayed visual recognition memory task, and only one (5%) on a delayed spatial recognition memory task. Our data suggest that dysregulation of the RAS-MAPK cascade may be associated with a pattern of reduced verbal recall memory performance but relative sparing of visual and spatial recognition memory.

Original languageEnglish
Pages (from-to)423-429
Number of pages7
JournalBehavior Genetics
Issue number3
Publication statusPublished - May 2011


  • LEOPARD syndrome
  • Long term memory
  • Noonan syndrome
  • RAS-MAPK cascade

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics


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