Long-term follow-up of the DERIVO® Embolization Device (DED®) for intracranial aneurysms: The Italian Multicentric Registry

Italian DERIVO® Registry Group, Mariangela Piano, Emilio Lozupone, Annalisa Sgoifo, Nunzio P. Nuzzi, Francesco Asteggiano, Guglielmo Pero, Luca Quilici, Giuseppe Iannucci, Paolo Cerini, Chiara Comelli, Simone Peschillo, Ciro Princiotta, Alessandro Pedicelli, Nicola Limbucci, Giuseppe Ganci, Guido Trasimeni, Elisa Ciceri, Giuseppe Faragò, Andrea GiorgianniMaurizio Denicola, Paolo Remida, Elvis Lafe, Dikran Mardighian, Maria Ruggiero, Guido A. Lazzarotti, Nicola Cavasin, Lucio Castellan, Luigi Chiumarulo, Nicola Burdi, Aldo Paolucci, Francesco Briganti, Massimiliano Natrella, Francesco P. Florio, Marco Pavia, Ivan Gallesio, Giuseppe Lucente, Luigi Gozzoli, Nevia Caputo, Simone Vagnarelli, Edoardo Boccardi, Luca Valvassori

Research output: Contribution to journalArticlepeer-review


BACKGROUND: The flow-diverter devices (FDDs) safety and effectiveness have been demonstrated by large series and meta-analyses. Due to the high occlusion rates and the acceptable morbidity rates of FDDs, the indications for their use are continuously expanding. We presented our Italian multicentric experience using the second generation of DERIVO® Embolization Device (DED®; Acandis, Pforzheim, Germany) to cure cerebral aneurysms, evaluating both middle and long-term safety and efficacy of this device. METHODS: Between July 2016 and September 2017 we collected 109 consecutive aneurysms in 108 patients treated using DED® during 109 endovascular procedures in 34 Italian centers (100/109 aneurysms were unruptured, 9/109 were ruptured). The collected data included patient demographics, aneurysm location and characteristics, baseline angiography, adverse event and serious adverse event information, morbidity and mortality rates, and pre- and post-treatment modified Rankin Scale scores. Midterm and long-term clinical, angiographic and cross-sectional CT/ MR follow-up were recorded and collected until December 2018. RESULTS: In 2/109 cases, DED® placement was classified as technical failures. The overall mortality and morbidity rates were respectively 6.5% and 5.5%. Overall DERIVO® related mortality and morbidity rates were respectively 0% and 4.6% (5 out of 108 patients). Midterm neuroimaging follow-up showed the complete or nearly complete occlusion of the aneurysm in 90% cases, which became 93% at long-term follow-up. Aneurysmal sac shrinking was observed in 65% of assessable aneurysms. CONCLUSIONS: Our multicentric experience using DED® for endovascular treatment of unruptured and ruptured aneurysms showed a high safety and efficacy profile, substantially equivalent or better compared to the other FDDs.
Original languageEnglish
Pages (from-to)361-368
Number of pages8
JournalJournal of Neurosurgical Sciences
Issue number3
Publication statusPublished - Jun 1 2021


  • Embolization
  • Intracranial aneurysm
  • Neurosurgery
  • Therapeutic


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