Long-term follow-up of Tako-Tsubo-like syndrome: A retrospective study of 22 cases

Alberto Valbusa, Francesco Abbadessa, Corinna Giachero, Massimo Vischi, Antonio Zingarelli, Roberto Olivieri, Luigi Oltrona Visconti

Research output: Contribution to journalArticlepeer-review


Objectives: To assess the late outcome of the Tako-Tsubo like syndrome in a community hospital in northern Italy. METHODS AND RESULTS: We reviewed 2233 patients who were admitted from 2001 to 2006 with diagnosis of acute coronary syndrome. Twenty-two patients (1%) presenting clinical and instrumental characteristics of Tako-Tsubo like syndrome were included in the study and prospectively underwent clinical and echocardiographic follow-up.All patients were women; aged 76 ± 7 years; 82% experienced a stress before the acute episode; 50% reported chest pain and dyspnoea also days before. Mean troponin peak value was 3.6 ± 3.3 μg/l. Mean acute echocardiographic ejection fraction was 40 ± 7%. Eighteen percent of them presented major in-hospital complications.At a mean follow-up time of 27 ± 19 months, 2 patients (9%) died because of ischemic stroke and renal failure, respectively, 14 (63%) were asymptomatic, 1 (5%) declared a paroxysmal episode of atrial fibrillation, and 5 (23%) still lamented dyspnoea or atypical chest pain. In all patients, typical apical ballooning disappeared and an increase in mean ejection fraction to 60 ± 4% was observed. CONCLUSION: After complications are promptly recognized and treated in the acute phase, prognosis of Tako-Tsubo like syndrome appears to be good at long-term follow-up, with a complete recovery of normal left ventricular function.

Original languageEnglish
Pages (from-to)805-809
Number of pages5
JournalJournal of Cardiovascular Medicine
Issue number8
Publication statusPublished - Aug 2008


  • Acute coronary syndrome
  • Apical ballooning syndrome
  • Cardiomyopathy
  • Follow-up
  • Prognosis
  • Tako-Tsubo

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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