Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes

R. Martino; A. Henseler; M. van Lint; N. Schaap; J. Finke; D. Beelen; S. Vigouroux; E. P. Alessandrino; G. J. Mufti; J. H. Veelken; B. Bruno; I. Yakoub-Agha; L. Volin; J. Maertens; R. Or; V. Leblond; M. Rovira; P. Kalhs; A. F. Alvarez; A. Vitek; J. Sierra; E. Wagner; M. Robin; T. de Witte; N. Kroger

doi:10.1038/bmt.2017.19 [doi]

Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes

R. Martino, A. Henseler, M. van Lint, N. Schaap, J. Finke, D. Beelen, S. Vigouroux, E. P. Alessandrino, G. J. Mufti, J. H. Veelken, B. Bruno, I. Yakoub-Agha, L. Volin, J. Maertens, R. Or, V. Leblond, M. Rovira, P. Kalhs, A. F. Alvarez, A. VitekJ. Sierra, E. Wagner, M. Robin, T. de Witte, N. Kroger

Research output: Contribution to journal › Article › peer-review

Abstract

This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0.4) and PFS (29 vs 21%, respectively, P=0.3). Non-relapse mortality was higher in MAC (40 vs 31%; P=0.1), especially in patients older than 50 years (50 vs 33%, P

Original language	English
Pages (from-to)	1107-1112
Number of pages	6
Journal	Bone Marrow Transplantation
Volume	52
Issue number	8
DOIs	https://doi.org/10.1038/bmt.2017.19 [doi]
Publication status	Published - Aug 1 2017

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Martino, R., Henseler, A., Lint, M. V., Schaap, N., Finke, J., Beelen, D., Vigouroux, S., Alessandrino, E. P., Mufti, G. J., Veelken, J. H., Bruno, B., Yakoub-Agha, I., Volin, L., Maertens, J., Or, R., Leblond, V., Rovira, M., Kalhs, P., Alvarez, A. F., ... Kroger, N. (2017). Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes. Bone Marrow Transplantation, 52(8), 1107-1112. https://doi.org/10.1038/bmt.2017.19 [doi]

Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes. / Martino, R.; Henseler, A.; Lint, M. van et al.

In: Bone Marrow Transplantation, Vol. 52, No. 8, 01.08.2017, p. 1107-1112.

Research output: Contribution to journal › Article › peer-review

Martino, R, Henseler, A, Lint, MV, Schaap, N, Finke, J, Beelen, D, Vigouroux, S, Alessandrino, EP, Mufti, GJ, Veelken, JH, Bruno, B, Yakoub-Agha, I, Volin, L, Maertens, J, Or, R, Leblond, V, Rovira, M, Kalhs, P, Alvarez, AF, Vitek, A, Sierra, J, Wagner, E, Robin, M, Witte, TD & Kroger, N 2017, 'Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes', Bone Marrow Transplantation, vol. 52, no. 8, pp. 1107-1112. https://doi.org/10.1038/bmt.2017.19 [doi]

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abstract = "This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0.4) and PFS (29 vs 21%, respectively, P=0.3). Non-relapse mortality was higher in MAC (40 vs 31%; P=0.1), especially in patients older than 50 years (50 vs 33%, P",

author = "R. Martino and A. Henseler and Lint, {M. van} and N. Schaap and J. Finke and D. Beelen and S. Vigouroux and Alessandrino, {E. P.} and Mufti, {G. J.} and Veelken, {J. H.} and B. Bruno and I. Yakoub-Agha and L. Volin and J. Maertens and R. Or and V. Leblond and M. Rovira and P. Kalhs and Alvarez, {A. F.} and A. Vitek and J. Sierra and E. Wagner and M. Robin and Witte, {T. de} and N. Kroger",

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AU - Martino, R.

AU - Henseler, A.

AU - Lint, M. van

AU - Schaap, N.

AU - Finke, J.

AU - Beelen, D.

AU - Vigouroux, S.

AU - Alessandrino, E. P.

AU - Mufti, G. J.

AU - Veelken, J. H.

AU - Bruno, B.

AU - Yakoub-Agha, I.

AU - Volin, L.

AU - Maertens, J.

AU - Or, R.

AU - Leblond, V.

AU - Rovira, M.

AU - Kalhs, P.

AU - Alvarez, A. F.

AU - Vitek, A.

AU - Sierra, J.

AU - Wagner, E.

AU - Robin, M.

AU - Witte, T. de

AU - Kroger, N.

N1 - LR: 20170803; JID: 8702459; 2016/09/29 00:00 [received]; 2016/12/20 00:00 [revised]; 2017/01/12 00:00 [accepted]; 2017/03/21 06:00 [pubmed]; 2017/03/21 06:00 [medline]; 2017/03/21 06:00 [entrez]; ppublish

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N2 - This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0.4) and PFS (29 vs 21%, respectively, P=0.3). Non-relapse mortality was higher in MAC (40 vs 31%; P=0.1), especially in patients older than 50 years (50 vs 33%, P

AB - This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0.4) and PFS (29 vs 21%, respectively, P=0.3). Non-relapse mortality was higher in MAC (40 vs 31%; P=0.1), especially in patients older than 50 years (50 vs 33%, P

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