Long term follow-up in high-risk congenital diaphragmatic hernia survivors: Patching the diaphragm affects the outcome

Laura Valfrè, Annabella Braguglia, Andrea Conforti, Francesco Morini, Alessandro Trucchi, Barbara Daniela Iacobelli, Antonella Nahom, Natalia Chukhlantseva, Andrea Dotta, Carlo Corchia, Pietro Bagolan

Research output: Contribution to journalArticlepeer-review


Background/Purpose: The increased survival rate reached in infants with congenital diaphragmatic hernia (CDH) has shown a concomitant increase in late morbidity. A recent report from CDH Study Group showed that dimension of diaphragmatic defect is the only independent risk factor of mortality. However, the influence of defect size on late morbidity is still controversial. The aim of the study was to evaluate the influence of patch repair (proxy of diaphragmatic defects size) on midterm morbidity. Methods: All high-risk (prenatal diagnosis and/or respiratory symptoms within 6 hours of life) CDH survivors treated at our institution from 2004 to 2008 were followed up in a multidisciplinary outpatient clinic as part of a longitudinal prospective study. Auxological, gastroesophageal, pulmonary, and orthopedic evaluations were performed at 6, 12, and 24 months of age. Patient outcomes were compared with respect to +/- patch repair. Results: Of 70 survivors, 61 (87%) were enrolled and prospectively evaluated in follow-up. Poorer auxological outcome, increased rate of gastroesophageal reflux, and altered pulmonary function test were observed during follow-up. Conclusions: Patch repair correlates with higher pulmonary, auxological, and gastroesophageal morbidity without increasing chest wall deformities at long-term follow-up.

Original languageEnglish
Pages (from-to)52-55
Number of pages4
JournalJournal of Pediatric Surgery
Issue number1
Publication statusPublished - Jan 2011


  • Chest wall deformities
  • Congenital diaphragmatic hernia
  • Follow-up
  • Gastroesophageal reflux
  • Growth
  • Patch repair

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health


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