Long-term effect of ovariectomy on dopamine-stimulated adenylate cyclase in rat striatum and nucleus accumbens

K. Kumakura; Madeleine Hoffman; Daniela Cocchi; M. Trabucchi; P. F. Spano; E. E. Müller

doi:10.1007/BF00426803

Long-term effect of ovariectomy on dopamine-stimulated adenylate cyclase in rat striatum and nucleus accumbens

K. Kumakura, Madeleine Hoffman, Daniela Cocchi, M. Trabucchi, P. F. Spano, E. E. Müller

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

The long-term effects on dopamine-sensitive adenylate cyclase of deprivation of gonadal steroids resulting from ovariectomy were studied in extrahypothalamic areas of the brain, i.e. corpus striatum and nucleus accumbens. The results obtained show that in both central nervous system areas dopamine- and apomorphine-stimulated adenylate cyclase were significantly reduced, suggesting that the function of dopamine receptors in these areas was depressed.

Original language	English
Pages (from-to)	13-16
Number of pages	4
Journal	Psychopharmacology
Volume	61
Issue number	1
DOIs	https://doi.org/10.1007/BF00426803
Publication status	Published - Jan 1979

Keywords

Corpus striatum
Dopamine sensitive adenylate cyclase
Gonadal steroids
Hypophysectomy
Nucleus accumbens
Ovariectomy

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00426803

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abstract = "The long-term effects on dopamine-sensitive adenylate cyclase of deprivation of gonadal steroids resulting from ovariectomy were studied in extrahypothalamic areas of the brain, i.e. corpus striatum and nucleus accumbens. The results obtained show that in both central nervous system areas dopamine- and apomorphine-stimulated adenylate cyclase were significantly reduced, suggesting that the function of dopamine receptors in these areas was depressed.",

keywords = "Corpus striatum, Dopamine sensitive adenylate cyclase, Gonadal steroids, Hypophysectomy, Nucleus accumbens, Ovariectomy",

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AU - Spano, P. F.

AU - Müller, E. E.

PY - 1979/1

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AB - The long-term effects on dopamine-sensitive adenylate cyclase of deprivation of gonadal steroids resulting from ovariectomy were studied in extrahypothalamic areas of the brain, i.e. corpus striatum and nucleus accumbens. The results obtained show that in both central nervous system areas dopamine- and apomorphine-stimulated adenylate cyclase were significantly reduced, suggesting that the function of dopamine receptors in these areas was depressed.

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KW - Dopamine sensitive adenylate cyclase

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KW - Hypophysectomy

KW - Nucleus accumbens

KW - Ovariectomy

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Long-term effect of ovariectomy on dopamine-stimulated adenylate cyclase in rat striatum and nucleus accumbens

Abstract

Keywords

ASJC Scopus subject areas

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