Locally advanced epithelial sinonasal tumors: The impact of multimodal approach. The Laryngoscope

Ester Orlandi, Stefano Cavalieri, Roberta Granata, Piero Nicolai, Paolo Castelnuovo, Cesare Piazza, Alberto Schreiber, Mario Turri-Zanoni, Pasquale Quattrone, Rosalba Miceli, Gabriele Infante, Fausto Sessa, Carla Facco, Giuseppina Calareso, Nicola Alessandro Iacovelli, Davide Mattavelli, Alberto Paderno, Carlo Resteghini, Laura Deborah Locati, Lisa LicitraPaolo Bossi

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: Outcomes of locally advanced epithelial sinonasal cancers remain unsatisfactory; moreover, only limited and heterogeneous data exist on prognostic factors. METHODS: We reviewed all consecutive patients with American Joint Committee Cancer stage III to IV epithelial sinonasal cancers treated with platinum-based induction chemotherapy (IC) followed by locoregional treatment between 1996 and 2015. RESULTS: We identified 69 patients treated with a multimodal approach (IC, surgery, radiotherapy). Overall, 44 patients recurred (64%). Of those, 19 patients received salvage surgery, but only four remained disease-free. Median overall survival (OS) was 62.5 months. Sinonasal neuroendocrine and small cell histotypes (P = 0.0085), neuroendocrine differentiation (P = 0.006), and lack of response to IC (P = 0.03) were associated with worse OS. In patients who recurred, median OS was 13 months since recurrence. Survival was longer in patients submitted to salvage surgery (44%) than in those receiving chemotherapy alone at recurrence (29.5 vs. 4.6 months). Patients with a clinical benefit after palliative chemotherapy had a longer median OS than those with disease progression (29.2 vs. 4.4 months; P
Original languageEnglish
Pages (from-to)857-865
Number of pages9
Issue number4
Publication statusPublished - 2020


  • Adult
  • Female
  • Humans
  • Male
  • Middle Aged
  • Combined Modality Therapy
  • Neoplasm Staging
  • Adolescent
  • Aged
  • Prognosis
  • *radiation
  • *surgery
  • Salvage Therapy
  • *induction chemotherapy
  • *multimodal treatment
  • *Sinonasal cancer
  • Palliative Care
  • Paranasal Sinus Neoplasms/mortality/pathology/*therapy


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