Liver transplantation in alcoholic patients: Impact of an alcohol addiction unit within a liver transplant center

Giovanni Addolorato; Antonio Mirijello; Lorenzo Leggio; Anna Ferrulli; Cristina D'Angelo; Gabriele Vassallo; Anthony Cossari; Giovanni Gasbarrini; Raffaele Landolfi; Salvatore Agnes; Antonio Gasbarrini; Valeria Abbate; Ludovico Abenavoli; Mariangela Antonelli; Eleonora Annicchiarico; Alfonso W. Avolio; Marco Biolato; Chiara Campanale; Esmeralda Capristo; Fabio Caputo; Valentina Cesario; Marco Castagneto; Nicoletta deMatthaeis; Chantal Favale; Daniele Ferrarese; Matteo Garcovich; Francesco Frongillo; Antonio Grieco; Noemi Malandrino; Luca Miele; Alessandro Milani; Antonio Nesci; Erida Nure; Giorgio Pelecca; Gilda Pepe; Paola Pietrogiacomi; Fabrizio Pizzolante; Maurizio Pompili; Francesca Romana Ponziani; GianLudovico Rapaccini; Laura Riccardi; Emanuele Rinninella; Michele C. Santoro; Gabriele Sganga; Massimo Siciliano; Vittoria Vero; Luisa Vonghia

doi:10.1111/acer.12117

Liver transplantation in alcoholic patients: Impact of an alcohol addiction unit within a liver transplant center

Giovanni Addolorato, Antonio Mirijello, Lorenzo Leggio, Anna Ferrulli, Cristina D'Angelo, Gabriele Vassallo, Anthony Cossari, Giovanni Gasbarrini, Raffaele Landolfi, Salvatore Agnes, Antonio Gasbarrini, Valeria Abbate, Ludovico Abenavoli, Mariangela Antonelli, Eleonora Annicchiarico, Alfonso W. Avolio, Marco Biolato, Chiara Campanale, Esmeralda Capristo, Fabio CaputoValentina Cesario, Marco Castagneto, Nicoletta deMatthaeis, Chantal Favale, Daniele Ferrarese, Matteo Garcovich, Francesco Frongillo, Antonio Grieco, Noemi Malandrino, Luca Miele, Alessandro Milani, Antonio Nesci, Erida Nure, Giorgio Pelecca, Gilda Pepe, Paola Pietrogiacomi, Fabrizio Pizzolante, Maurizio Pompili, Francesca Romana Ponziani, GianLudovico Rapaccini, Laura Riccardi, Emanuele Rinninella, Michele C. Santoro, Gabriele Sganga, Massimo Siciliano, Vittoria Vero, Luisa Vonghia

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Many concerns about liver transplantation in alcoholic patients are related to the risk of alcohol recidivism. Starting from 2002, an Alcohol Addiction Unit (AAU) was formed within the liver transplant center for the management of alcoholic patients affected by end-stage liver disease and included in the waiting list for transplantation. We evaluated retrospectively the impact of the AAU on alcohol recidivism after transplantation. The relationship between alcohol recidivism and the duration of alcohol abstinence before transplant was evaluated as well. Methods: Between 1995 and 2010, 92 cirrhotic alcoholic patients underwent liver transplantation. Clinical evaluation and management of alcohol use in these patients was provided by psychiatrists with expertise in addiction medicine not affiliated to the liver transplant center before 2002 (n = 37; group A), or by the clinical staff of the AAU within the liver transplant center starting from 2002 (n = 55; group B). Results: Group B, as compared with group A, showed a significantly lower prevalence of alcohol recidivism (16.4 vs. 35.1%; p = 0.038) and a significantly lower mortality (14.5 vs. 37.8%; p = 0.01). Furthermore, an analysis of group B patients with either ≥6 or

Original language	English
Pages (from-to)	1601-1608
Number of pages	8
Journal	Alcoholism: Clinical and Experimental Research
Volume	37
Issue number	9
DOIs	https://doi.org/10.1111/acer.12117
Publication status	Published - Sept 2013

Keywords

Alcohol Addiction Unit
Alcohol Dependence
Alcohol Recidivism
Alcoholism
Orthotopic Liver Transplantation

ASJC Scopus subject areas

Medicine (miscellaneous)
Psychiatry and Mental health
Toxicology

Access to Document

10.1111/acer.12117

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Addolorato, G., Mirijello, A., Leggio, L., Ferrulli, A., D'Angelo, C., Vassallo, G., Cossari, A., Gasbarrini, G., Landolfi, R., Agnes, S., Gasbarrini, A., Abbate, V., Abenavoli, L., Antonelli, M., Annicchiarico, E., Avolio, A. W., Biolato, M., Campanale, C., Capristo, E., ... Vonghia, L. (2013). Liver transplantation in alcoholic patients: Impact of an alcohol addiction unit within a liver transplant center. Alcoholism: Clinical and Experimental Research, 37(9), 1601-1608. https://doi.org/10.1111/acer.12117

Addolorato, G, Mirijello, A, Leggio, L, Ferrulli, A, D'Angelo, C, Vassallo, G, Cossari, A, Gasbarrini, G, Landolfi, R, Agnes, S, Gasbarrini, A, Abbate, V, Abenavoli, L, Antonelli, M, Annicchiarico, E, Avolio, AW, Biolato, M, Campanale, C, Capristo, E, Caputo, F, Cesario, V, Castagneto, M, deMatthaeis, N, Favale, C, Ferrarese, D, Garcovich, M, Frongillo, F, Grieco, A, Malandrino, N, Miele, L, Milani, A, Nesci, A, Nure, E, Pelecca, G, Pepe, G, Pietrogiacomi, P, Pizzolante, F, Pompili, M, Romana Ponziani, F, Rapaccini, G, Riccardi, L, Rinninella, E, Santoro, MC, Sganga, G, Siciliano, M, Vero, V & Vonghia, L 2013, 'Liver transplantation in alcoholic patients: Impact of an alcohol addiction unit within a liver transplant center', Alcoholism: Clinical and Experimental Research, vol. 37, no. 9, pp. 1601-1608. https://doi.org/10.1111/acer.12117

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title = "Liver transplantation in alcoholic patients: Impact of an alcohol addiction unit within a liver transplant center",

abstract = "Background: Many concerns about liver transplantation in alcoholic patients are related to the risk of alcohol recidivism. Starting from 2002, an Alcohol Addiction Unit (AAU) was formed within the liver transplant center for the management of alcoholic patients affected by end-stage liver disease and included in the waiting list for transplantation. We evaluated retrospectively the impact of the AAU on alcohol recidivism after transplantation. The relationship between alcohol recidivism and the duration of alcohol abstinence before transplant was evaluated as well. Methods: Between 1995 and 2010, 92 cirrhotic alcoholic patients underwent liver transplantation. Clinical evaluation and management of alcohol use in these patients was provided by psychiatrists with expertise in addiction medicine not affiliated to the liver transplant center before 2002 (n = 37; group A), or by the clinical staff of the AAU within the liver transplant center starting from 2002 (n = 55; group B). Results: Group B, as compared with group A, showed a significantly lower prevalence of alcohol recidivism (16.4 vs. 35.1%; p = 0.038) and a significantly lower mortality (14.5 vs. 37.8%; p = 0.01). Furthermore, an analysis of group B patients with either ≥6 or ",

keywords = "Alcohol Addiction Unit, Alcohol Dependence, Alcohol Recidivism, Alcoholism, Orthotopic Liver Transplantation",

author = "Giovanni Addolorato and Antonio Mirijello and Lorenzo Leggio and Anna Ferrulli and Cristina D'Angelo and Gabriele Vassallo and Anthony Cossari and Giovanni Gasbarrini and Raffaele Landolfi and Salvatore Agnes and Antonio Gasbarrini and Valeria Abbate and Ludovico Abenavoli and Mariangela Antonelli and Eleonora Annicchiarico and Avolio, {Alfonso W.} and Marco Biolato and Chiara Campanale and Esmeralda Capristo and Fabio Caputo and Valentina Cesario and Marco Castagneto and Nicoletta deMatthaeis and Chantal Favale and Daniele Ferrarese and Matteo Garcovich and Francesco Frongillo and Antonio Grieco and Noemi Malandrino and Luca Miele and Alessandro Milani and Antonio Nesci and Erida Nure and Giorgio Pelecca and Gilda Pepe and Paola Pietrogiacomi and Fabrizio Pizzolante and Maurizio Pompili and {Romana Ponziani}, Francesca and GianLudovico Rapaccini and Laura Riccardi and Emanuele Rinninella and Santoro, {Michele C.} and Gabriele Sganga and Massimo Siciliano and Vittoria Vero and Luisa Vonghia",

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T2 - Impact of an alcohol addiction unit within a liver transplant center

AU - Addolorato, Giovanni

AU - Mirijello, Antonio

AU - Leggio, Lorenzo

AU - Ferrulli, Anna

AU - D'Angelo, Cristina

AU - Vassallo, Gabriele

AU - Cossari, Anthony

AU - Gasbarrini, Giovanni

AU - Landolfi, Raffaele

AU - Agnes, Salvatore

AU - Gasbarrini, Antonio

AU - Abbate, Valeria

AU - Abenavoli, Ludovico

AU - Antonelli, Mariangela

AU - Annicchiarico, Eleonora

AU - Avolio, Alfonso W.

AU - Biolato, Marco

AU - Campanale, Chiara

AU - Capristo, Esmeralda

AU - Caputo, Fabio

AU - Cesario, Valentina

AU - Castagneto, Marco

AU - deMatthaeis, Nicoletta

AU - Favale, Chantal

AU - Ferrarese, Daniele

AU - Garcovich, Matteo

AU - Frongillo, Francesco

AU - Grieco, Antonio

AU - Malandrino, Noemi

AU - Miele, Luca

AU - Milani, Alessandro

AU - Nesci, Antonio

AU - Nure, Erida

AU - Pelecca, Giorgio

AU - Pepe, Gilda

AU - Pietrogiacomi, Paola

AU - Pizzolante, Fabrizio

AU - Pompili, Maurizio

AU - Romana Ponziani, Francesca

AU - Rapaccini, GianLudovico

AU - Riccardi, Laura

AU - Rinninella, Emanuele

AU - Santoro, Michele C.

AU - Sganga, Gabriele

AU - Siciliano, Massimo

AU - Vero, Vittoria

AU - Vonghia, Luisa

PY - 2013/9

Y1 - 2013/9

N2 - Background: Many concerns about liver transplantation in alcoholic patients are related to the risk of alcohol recidivism. Starting from 2002, an Alcohol Addiction Unit (AAU) was formed within the liver transplant center for the management of alcoholic patients affected by end-stage liver disease and included in the waiting list for transplantation. We evaluated retrospectively the impact of the AAU on alcohol recidivism after transplantation. The relationship between alcohol recidivism and the duration of alcohol abstinence before transplant was evaluated as well. Methods: Between 1995 and 2010, 92 cirrhotic alcoholic patients underwent liver transplantation. Clinical evaluation and management of alcohol use in these patients was provided by psychiatrists with expertise in addiction medicine not affiliated to the liver transplant center before 2002 (n = 37; group A), or by the clinical staff of the AAU within the liver transplant center starting from 2002 (n = 55; group B). Results: Group B, as compared with group A, showed a significantly lower prevalence of alcohol recidivism (16.4 vs. 35.1%; p = 0.038) and a significantly lower mortality (14.5 vs. 37.8%; p = 0.01). Furthermore, an analysis of group B patients with either ≥6 or

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KW - Alcohol Addiction Unit

KW - Alcohol Dependence

KW - Alcohol Recidivism

KW - Alcoholism

KW - Orthotopic Liver Transplantation

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Liver transplantation in alcoholic patients: Impact of an alcohol addiction unit within a liver transplant center

Abstract

Keywords

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