TY - JOUR
T1 - Liver steatosis in chronic hepatitis C
T2 - A morphological sign suggesting infection with HCV genotype 3
AU - Rubbia-Brandt, L.
AU - Leandro, G.
AU - Spahr, L.
AU - Giostra, E.
AU - Quadri, R.
AU - Malé, P. J.
AU - Negro, F.
PY - 2001
Y1 - 2001
N2 - Aims: To identify factors associated with liver steatosis in chronic hepatitis C. Methods and results: Occurrence and severity of liver steatosis in 254 chronic hepatitis C patients were compared with presence of alcohol abuse, body mass index (BMI) > 26, history of intravenous drug addiction and hepatitis C virus (HCV) genotype. Steatosis was found in 109 (43%) patients. The occurrence of steatosis was significantly associated with ongoing alcohol abuse (P = 0.03) or HCV genotype 3 (P = 0.003), but not with BMI > 26. A moderate to severe steatosis was present in 60% of patients infected with HCV genotype 3, irrespective of the presence of alcohol abuse, BMI > 26 or history of intravenous drug addiction. Using a multivariable stepwise logistic regression analysis, infection with genotype 3 had an odds ratio (OR) of 10 (95% confidence interval (CI) = 4.56-22) for a liver steatosis, whereas the presence of a cirrhosis at histology had an OR = 0.256 (95% CI = 0.07-0.92). Conclusions: A moderate to severe degree of steatosis of the liver is a morphological sign suggestive of infection with HCV genotype 3, independent of other risk factors of a fatty liver, but it may disappear at late stages of the disease.
AB - Aims: To identify factors associated with liver steatosis in chronic hepatitis C. Methods and results: Occurrence and severity of liver steatosis in 254 chronic hepatitis C patients were compared with presence of alcohol abuse, body mass index (BMI) > 26, history of intravenous drug addiction and hepatitis C virus (HCV) genotype. Steatosis was found in 109 (43%) patients. The occurrence of steatosis was significantly associated with ongoing alcohol abuse (P = 0.03) or HCV genotype 3 (P = 0.003), but not with BMI > 26. A moderate to severe steatosis was present in 60% of patients infected with HCV genotype 3, irrespective of the presence of alcohol abuse, BMI > 26 or history of intravenous drug addiction. Using a multivariable stepwise logistic regression analysis, infection with genotype 3 had an odds ratio (OR) of 10 (95% confidence interval (CI) = 4.56-22) for a liver steatosis, whereas the presence of a cirrhosis at histology had an OR = 0.256 (95% CI = 0.07-0.92). Conclusions: A moderate to severe degree of steatosis of the liver is a morphological sign suggestive of infection with HCV genotype 3, independent of other risk factors of a fatty liver, but it may disappear at late stages of the disease.
KW - HCV genotypes
KW - Liver steatosis
KW - Viral cytopathic effect
KW - Viral pathogenesis
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U2 - 10.1046/j.1365-2559.2001.01208.x
DO - 10.1046/j.1365-2559.2001.01208.x
M3 - Article
C2 - 11493327
AN - SCOPUS:0035572430
SN - 0309-0167
VL - 39
SP - 119
EP - 124
JO - Histopathology
JF - Histopathology
IS - 2
ER -