Liquid biopsy and NSCLC

Research output: Contribution to journalReview articlepeer-review


In the era of high-throughput molecular screening and personalized medicine, difficulty in determining whether cancer mutations are truly 'actionable' remains a gray zone in NSCLC. The most important prerequisite to perform such investigations is the tumor tissue retrieval via biopsy at diagnosis and after occurrence of resistance. Blood-based liquid biopsy as circulating tumor cells, circulating tumor DNA and exosomes can offer a fast and non-invasive method to elucidate the genetic heterogeneity of patients, the screening and patient stratification and give a dynamic surveillance for tumor progression and monitor treatments response. Here we prospectively discuss the three main approaches in the blood-biopsy field of lung cancer patients and its clinical applications in patient management. We also outline some of the analytical challenges that remain for liquid biopsy techniques in demonstrating that it could represent a true and actionable picture in lung cancer management for the implementation into clinical routine.

Original languageEnglish
Pages (from-to)91-104
Number of pages14
JournalLung Cancer Management
Issue number2
Publication statusPublished - Jun 1 2016


  • CTCs
  • ctDNA
  • early detection
  • exosomes
  • liquid biopsy
  • minimal residual disease
  • personalized medicine
  • resistance monitoring
  • therapy options
  • tumor burden
  • tumor evolution

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine


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