Life-sparing effect of human cord blood-mesenchymal stem cells in experimental acute kidney injury

Marina Morigi, Cinzia Rota, Tiziana Montemurro, Elisa Montelatici, Viviana Lo Cicero, Barbara Imberti, Mauro Abbate, Carla Zoja, Paola Cassis, Lorena Longaretti, Paolo Rebulla, Martino Introna, Chiara Capelli, Ariela Benigni, Giuseppe Remuzzi, Lorenza Lazzari

Research output: Contribution to journalArticlepeer-review


In search for new sources of mesenchymal stem cells (MSCs) for renal repair in acute kidney injury (AKI), we investigated the potential of human cord blood (CB)-MSCs to cure mice with AKI. Infusion of CB-MSCs in immunodeficient mice with cisplatin-induced AKI ameliorated both renal function and tubular cell injury, and prolonged survival. Transplanted CB-MSCs localized in peritubular areas, limited capillary alterations and neutrophil infiltration. Apoptosis reduced and tubular cell proliferation increased by virtue of stem cell capacity to produce growth factors. The reno-protective effect of CB-MSCs was further confirmed by their ability to inhibit oxidative damage and to induce the prosurvival factor Akt in tubular cells. The evidence that CB-MSCs in vitro increased the production of growth factors and inhibited IL-1β and TNFα synthesis when cocultured with damaged proximal tubular cells indicates a regenerative and anti-inflammatory action of stem cell treatment. Altogether these results highlight the potential of human CB-MSCs as future cell therapy for testing in human AKI.

Original languageEnglish
Pages (from-to)513-522
Number of pages10
JournalStem Cells
Issue number3
Publication statusPublished - Mar 31 2010


  • Acute renal failure
  • Human cord blood-mesenchymal stem cells
  • Kidney repair
  • Tubular cells

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Molecular Medicine


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