Levofloxacin and Tobramycin for Severe Bacterial Keratouveitis

Massimo Accorinti; Lorena Colao; Marta Gilardi; Michela Cecere; Alessandra Salotti; Francesca Romana Pesci

doi:10.3109/09273948.2015.1010093

Levofloxacin and Tobramycin for Severe Bacterial Keratouveitis

Massimo Accorinti, Lorena Colao, Marta Gilardi, Michela Cecere, Alessandra Salotti, Francesca Romana Pesci

Fondazione G.B. Bietti

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To report on clinical features and outcome of severe bacterial keratouveitis. Methods: Twenty patients with severe bacterial keratouveitis treated with topical tobramycin and levofloxacin and oral levofloxacin were included. Main outcome measures were ulcers location, bacterial isolates, risk factors, visual prognosis. Results: Centrally located ulcer/abscess was present in 65% of patients. Contact lens (CL) wear was the most common risk factor (70%). Bacterial isolates were observed in 58% of patients, none resistant to tobramycin and levofloxacin. Pseudomonas aeruginosa was found in 47% of positive cases and in 64% of CL wearers. After therapy, the mean visual acuity improved significantly (p

Original language	English
Journal	Ocular Immunology and Inflammation
DOIs	https://doi.org/10.3109/09273948.2015.1010093
Publication status	Accepted/In press - Jul 10 2015

Keywords

Antibiotic therapy
bacterial keratitis
contact lens
intraocular inflammation
Pseudomonas aeruginosa

ASJC Scopus subject areas

Ophthalmology
Immunology and Allergy

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10.3109/09273948.2015.1010093

Cite this

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title = "Levofloxacin and Tobramycin for Severe Bacterial Keratouveitis",

abstract = "Purpose: To report on clinical features and outcome of severe bacterial keratouveitis. Methods: Twenty patients with severe bacterial keratouveitis treated with topical tobramycin and levofloxacin and oral levofloxacin were included. Main outcome measures were ulcers location, bacterial isolates, risk factors, visual prognosis. Results: Centrally located ulcer/abscess was present in 65% of patients. Contact lens (CL) wear was the most common risk factor (70%). Bacterial isolates were observed in 58% of patients, none resistant to tobramycin and levofloxacin. Pseudomonas aeruginosa was found in 47% of positive cases and in 64% of CL wearers. After therapy, the mean visual acuity improved significantly (p ",

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AU - Accorinti, Massimo

AU - Colao, Lorena

AU - Gilardi, Marta

AU - Cecere, Michela

AU - Salotti, Alessandra

AU - Pesci, Francesca Romana

PY - 2015/7/10

Y1 - 2015/7/10

N2 - Purpose: To report on clinical features and outcome of severe bacterial keratouveitis. Methods: Twenty patients with severe bacterial keratouveitis treated with topical tobramycin and levofloxacin and oral levofloxacin were included. Main outcome measures were ulcers location, bacterial isolates, risk factors, visual prognosis. Results: Centrally located ulcer/abscess was present in 65% of patients. Contact lens (CL) wear was the most common risk factor (70%). Bacterial isolates were observed in 58% of patients, none resistant to tobramycin and levofloxacin. Pseudomonas aeruginosa was found in 47% of positive cases and in 64% of CL wearers. After therapy, the mean visual acuity improved significantly (p

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KW - bacterial keratitis

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KW - intraocular inflammation

KW - Pseudomonas aeruginosa

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Levofloxacin and Tobramycin for Severe Bacterial Keratouveitis

Abstract

Keywords

ASJC Scopus subject areas

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