Levofloxacin and Tobramycin for Severe Bacterial Keratouveitis

Massimo Accorinti, Lorena Colao, Marta Gilardi, Michela Cecere, Alessandra Salotti, Francesca Romana Pesci

Research output: Contribution to journalArticlepeer-review


Purpose: To report on clinical features and outcome of severe bacterial keratouveitis. Methods: Twenty patients with severe bacterial keratouveitis treated with topical tobramycin and levofloxacin and oral levofloxacin were included. Main outcome measures were ulcers location, bacterial isolates, risk factors, visual prognosis. Results: Centrally located ulcer/abscess was present in 65% of patients. Contact lens (CL) wear was the most common risk factor (70%). Bacterial isolates were observed in 58% of patients, none resistant to tobramycin and levofloxacin. Pseudomonas aeruginosa was found in 47% of positive cases and in 64% of CL wearers. After therapy, the mean visual acuity improved significantly (p 

Original languageEnglish
JournalOcular Immunology and Inflammation
Publication statusAccepted/In press - Jul 10 2015


  • Antibiotic therapy
  • bacterial keratitis
  • contact lens
  • intraocular inflammation
  • Pseudomonas aeruginosa

ASJC Scopus subject areas

  • Ophthalmology
  • Immunology and Allergy


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