Leptin affects the inflammatory response after STEMI: Nutrition, Metabolism and Cardiovascular Diseases

A. Demarchi, I. Mazzucchelli, A. Somaschini, S. Cornara, V. Dusi, A.M. Mirizzi, M. Ruffinazzi, G. Crimi, M. Ferlini, M. Gnecchi, L.O. Visconti, S. De Servi, G.M. De Ferrari

Research output: Contribution to journalArticlepeer-review


Leptin is an adipose tissue-derived hormone primarily involved in the regulation of food intake. Leptine has been shown to have a much broader role than just regulating body weight and appetite in response to food intake: among the others, it has been associated with increased ROS production and inflammation, factors involved in the restoration of an effective myocardial reperfusion after myocardial revascularization. Our study, to our best knowledge, is the first showing a direct relationship between leptin serum levels, inflammatory mediators of the ischemia reperfusion damage and effective myocardial reperfusion in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention. Our findings suggest that leptin serum levels are directly associated with the inflammatory response during an acute myocardial infarction and may have a role in risk stratification in this clinical setting. © 2020 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University
Original languageEnglish
Pages (from-to)922-924
Number of pages3
JournalNutr. Metab. Cardiovasc. Dis.
Issue number6
Publication statusPublished - 2020


  • Acute inflammation and ischaemia-reperfusion damage
  • Leptin
  • ST elevation myocardial infarction
  • C reactive protein
  • interleukin 6
  • leptin
  • reactive oxygen metabolite
  • autacoid
  • biological marker
  • IL6 protein, human
  • LEP protein, human
  • acute heart infarction
  • adipose tissue
  • adult
  • aged
  • appetite
  • Article
  • body weight
  • clinical article
  • food intake
  • heart muscle reperfusion
  • heart muscle revascularization
  • human
  • hypertension
  • inflammation
  • male
  • middle aged
  • percutaneous coronary intervention
  • priority journal
  • reperfusion injury
  • ST segment elevation myocardial infarction
  • adverse event
  • blood
  • metabolism
  • time factor
  • treatment outcome
  • Biomarkers
  • C-Reactive Protein
  • Humans
  • Inflammation Mediators
  • Interleukin-6
  • Male
  • Percutaneous Coronary Intervention
  • ST Elevation Myocardial Infarction
  • Time Factors
  • Treatment Outcome


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