@article{9e1c0ea362c44a7fa818ad5d36f666bb,
title = "Leptin affects the inflammatory response after STEMI: Nutrition, Metabolism and Cardiovascular Diseases",
abstract = "Leptin is an adipose tissue-derived hormone primarily involved in the regulation of food intake. Leptine has been shown to have a much broader role than just regulating body weight and appetite in response to food intake: among the others, it has been associated with increased ROS production and inflammation, factors involved in the restoration of an effective myocardial reperfusion after myocardial revascularization. Our study, to our best knowledge, is the first showing a direct relationship between leptin serum levels, inflammatory mediators of the ischemia reperfusion damage and effective myocardial reperfusion in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention. Our findings suggest that leptin serum levels are directly associated with the inflammatory response during an acute myocardial infarction and may have a role in risk stratification in this clinical setting. {\textcopyright} 2020 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University",
keywords = "Acute inflammation and ischaemia-reperfusion damage, Leptin, ST elevation myocardial infarction, C reactive protein, interleukin 6, leptin, reactive oxygen metabolite, autacoid, biological marker, IL6 protein, human, LEP protein, human, acute heart infarction, adipose tissue, adult, aged, appetite, Article, body weight, clinical article, food intake, heart muscle reperfusion, heart muscle revascularization, human, hypertension, inflammation, male, middle aged, percutaneous coronary intervention, priority journal, reperfusion injury, ST segment elevation myocardial infarction, adverse event, blood, metabolism, time factor, treatment outcome, Biomarkers, C-Reactive Protein, Humans, Inflammation Mediators, Interleukin-6, Male, Percutaneous Coronary Intervention, ST Elevation Myocardial Infarction, Time Factors, Treatment Outcome",
author = "A. Demarchi and I. Mazzucchelli and A. Somaschini and S. Cornara and V. Dusi and A.M. Mirizzi and M. Ruffinazzi and G. Crimi and M. Ferlini and M. Gnecchi and L.O. Visconti and {De Servi}, S. and {De Ferrari}, G.M.",
note = "Cited By :2 Export Date: 5 March 2021 Correspondence Address: Demarchi, A.; Department of Molecular Medicine, Italy; email: andrea.demarchi02@universitadipavia.it Chemicals/CAS: C reactive protein, 9007-41-4; Biomarkers; C-Reactive Protein; IL6 protein, human; Inflammation Mediators; Interleukin-6; LEP protein, human; Leptin References: Bodary, P.F., Westrick, R.J., Wickenheiser, K.J., Shen, Y., Eitzman, D.T., Effect of leptin on arterial thrombosis following vascular injury in mice (2002) Jama, 287, pp. 1706-1709; S{\"o}derberg, S., Olsson, T., Eliasson, M., Johnson, O., Ahre{\^a}n, B., Plasma leptin levels are associated with abnormal fibrinolysis in men and postmenopausal women (1999) J Intern Med, 245, pp. 533-543; Yu, L., Wang, Y., Zhou, X., Huang, B., Wang, M., Li, X., Leptin injection into the left stellate ganglion augments ischemia-related ventricular arrhythmias via sympathetic nerve activation (2018) Heart Rhythm, 15, pp. 597-606; D'Elia, L., Manfredi, M., Perna, L., Iacone, R., Russo, O., Strazzullo, P., Circulating leptin levels predict the decline in renal function with age in a sample of adult men (The Olivetti Heart Study) (2019) Intern Emerg Med, 14, pp. 507-513; Galletti, F., D'Elia, L., Barba, G., Siani, A., Cappuccio, F.P., Farinaro, E., High-circulating leptin levels are associated with greater risk of hypertension in men independently of body mass and insulin resistance: results of an eight-year follow-up study (2008) J Clin Endocrinol Metab, 93, pp. 3922-3926; Galletti, F., D'Elia, L., De Palma, D., Russo, O., Barba, G., Siani, A., Hyperleptinemia is associated with hypertension, systemic inflammation and insulin resistance in overweight but not in normal weight men (2012) Nutr Metabol Cardiovasc Dis, 22, pp. 300-306; D'Elia, L., Strazzullo, P., Iacone, R., Russo, O., Galletti, F., Leptin levels predict the development of insulin resistance in a sample of adult men (The Olivetti Heart Study) (2019) Nutr Metabol Cardiovasc Dis, 29, pp. 39-44; Galletti, F., Barbato, A., Versiero, M., Iacone, R., Russo, O., Barba, G., Circulating leptin levels predict the development of metabolic syndrome in middle-aged men: an 8-year follow-up study (2007) J Hypertens, 25, pp. 1671-1677; Romero-Corral, A., Sierra-Johnson, J., Lopez-Jimenez, F., Thomas, R.J., Singh, P., Hoffmann, M., Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population (2008) Nat Clin Pract Cardiovasc Med, 5, pp. 418-425; D'Elia, L., Giaquinto, A., Cappuccio, F.P., Iacone, R., Russo, O., Strazzullo, P., Circulating leptin is associated with serum uric acid level and its tubular reabsorption in a sample of adult middle-aged men (2019) J Endocrinol Invest; Mandurino-Mirizzi, A., Demarchi, A., Ruffinazzi, M., Cornara, S., Somaschini, A., Crimi, G., Serum uric acid may modulate the inflammatory response after primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction (2020) J Cardiovasc Med; Yellon, D.M., Hausenloy, D.J., Myocardial reperfusion injury (2007) N Engl J Med, 357, pp. 1121-1135; Ridker, P.M., Cannon, C.P., Morrow, D., Rifai, N., Rose, L.M., McCabe, C.H., C-reactive protein levels and outcomes after statin therapy (2005) N Engl J Med, 352, pp. 20-28; De Servi, S., Mariani, M., Mariani, G., Mazzone, A., C-reactive protein increase in unstable coronary disease: cause or effect? (2005) J Am Coll Cardiol, 46, pp. 1496-1502; Ridker, P.M., Everett, B.M., Thuren, T., MacFadyen, J.G., Chang, W.H., Ballantyne, C., Antiinflammatory therapy with canakinumab for atherosclerotic disease (2017) N Engl J Med, 377, pp. 1119-1131; Sattar, N., Wannamethee, G., Sarwar, N., Chernova, J., Lawlor, D.A., Kelly, A., Leptin and coronary heart disease: prospective study and systematic review (2009) J Am Coll Cardiol, 53, pp. 167-175; Zeymer, U., Schr{\"o}der, K., Wegscheider, K., Senges, J., Neuhaus, K.L., Schr{\"o}der, R., ST resolution in a single electrocardiographic lead: a simple and accurate predictor of cardiac mortality in patients with fibrinolytic therapy for acute ST-elevation myocardial infarction (2005) Am J Cardiol, 149, pp. 91-97; Wolk, R., Berger, P., Lennon, R.J., Brilakis, E.S., Johnson, B.D., Somers, V.K., Plasma leptin and prognosis in patients with established coronary atherosclerosis (2004) J Am Coll Cardiol, 44, pp. 1819-1824; Taneli, F., Yegane, S., Ulman, C., Tikiz, H., Bilge, A.R., Ari, Z., Increased serum leptin concentrations in patients with chronic stable angina pectoris and ST-elevated myocardial infarction (2006) Angiology, 57, pp. 267-272",
year = "2020",
doi = "10.1016/j.numecd.2020.02.004",
language = "English",
volume = "30",
pages = "922--924",
journal = "Nutr. Metab. Cardiovasc. Dis.",
issn = "0939-4753",
publisher = "Elsevier B.V.",
number = "6",
}