Left ventricular strain in chronic ischemic mitral regurgitation in relation to mitral tethering pattern

Sandro Gelsomino, Leen Van Garsse, Fabiana Lucà, Orlando Parise, Emile Cheriex, Carmelo Massimiliano Rao, Gian Franco Gensini, Jos Maessen

Research output: Contribution to journalArticlepeer-review


Background: The aim of this retrospective study was to explore whether different tethering patterns in chronic ischemic mitral regurgitation have different distributions of left ventricular (LV) systolic longitudinal, circumferential, and radial strain before and after mitral valve repair. Methods: Sixty-one patients with chronic ischemic mitral regurgitation who underwent mitral repair were divided on the basis of the preoperative anterior/posterior tethering angle ratio (cutoff value, 0.76). There were 29 patients with symmetric (group 1) and 32 with asymmetric (group 2) preoperative tethering patterns. Assessment of longitudinal peak systolic strain was performed offline by applying speckle-tracking imaging to the apical two-chamber, three-chamber, and four-chamber views of the left ventricle. Peak systolic radial and circumferential strain was obtained from short-axis views at the basal, middle, and apical levels. Twenty healthy subjects served as controls. Results: In group 1, baseline LV strain was impaired in all LV segments, with the worst values in the anterolateral, anterior, and inferolateral segments at the midventricular and basal levels. In contrast, asymmetric patients showed higher values in the inferior and inferoseptal walls and values closer to normal in the other segments. After surgery, all strain measurements showed significant improvements in all LV segments in group 2, whereas in Group 1, strain worsened in the inferoseptal, inferior, and anteroseptal walls and did not change in the other segments. Conclusions: Patients with baseline symmetric tethering patterns showed more extensive abnormal strain, which was observed in all LV segments and was not reverted by surgery. These findings require confirmation in additional larger studies.

Original languageEnglish
JournalJournal of the American Society of Echocardiography
Issue number4
Publication statusPublished - Apr 2013


  • Ischemic mitral regurgitation
  • Mitral valve
  • Strain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Left ventricular strain in chronic ischemic mitral regurgitation in relation to mitral tethering pattern'. Together they form a unique fingerprint.

Cite this