TY - JOUR
T1 - Left ventricular dyssynchrony assessed by two three-dimensional imaging modalities
T2 - Phase analysis of gated myocardial perfusion SPECT and tri-plane tissue Doppler imaging
AU - Ajmone Marsan, Nina
AU - Henneman, Maureen M.
AU - Chen, Ji
AU - Ypenburg, Claudia
AU - Dibbets, Petra
AU - Ghio, Stefano
AU - Bleeker, Gabe B.
AU - Stokkel, Marcel P.
AU - Van Der Wall, Ernst E.
AU - Tavazzi, Luigi
AU - Garcia, Ernest V.
AU - Bax, Jeroen J.
PY - 2008/1
Y1 - 2008/1
N2 - Purpose: To compare left ventricular (LV) dyssynchrony assessment by phase analysis from gated myocardial perfusion SPECT (GMPS) with LV dyssynchrony assessment by tri-plane tissue Doppler imaging (TDI). Baseline LV dyssynchrony assessed with standard deviation (SD) of time-to-peak systolic velocity of 12 LV segments (Ts-SD) with TDI has proven to be a powerful predictor of response to CRT. Information on LV dyssynchrony can also be provided by GMPS with phase analysis of regional LV maximal count changes throughout the cardiac cycle. Methods: Forty heart failure patients, referred for evaluation of potential eligibility for CRT, underwent both 3D echocardiography, with tri-plane TDI, and resting GMPS. From tri-plane TDI, Ts-SD was used as a validated parameter of LV dyssynchrony and compared with different indices (histogram bandwidth, phase SD, histogram skewness and kurtosis) derived from phase analysis of GMPS. Results: Histogram bandwidth and phase SD showed good correlation with Ts-SD (r=0.77 and r=0.74, p
AB - Purpose: To compare left ventricular (LV) dyssynchrony assessment by phase analysis from gated myocardial perfusion SPECT (GMPS) with LV dyssynchrony assessment by tri-plane tissue Doppler imaging (TDI). Baseline LV dyssynchrony assessed with standard deviation (SD) of time-to-peak systolic velocity of 12 LV segments (Ts-SD) with TDI has proven to be a powerful predictor of response to CRT. Information on LV dyssynchrony can also be provided by GMPS with phase analysis of regional LV maximal count changes throughout the cardiac cycle. Methods: Forty heart failure patients, referred for evaluation of potential eligibility for CRT, underwent both 3D echocardiography, with tri-plane TDI, and resting GMPS. From tri-plane TDI, Ts-SD was used as a validated parameter of LV dyssynchrony and compared with different indices (histogram bandwidth, phase SD, histogram skewness and kurtosis) derived from phase analysis of GMPS. Results: Histogram bandwidth and phase SD showed good correlation with Ts-SD (r=0.77 and r=0.74, p
KW - Gated SPECT
KW - Heart failure
KW - LV dyssynchrony
KW - Nuclear imaging
KW - TDI
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U2 - 10.1007/s00259-007-0539-6
DO - 10.1007/s00259-007-0539-6
M3 - Article
C2 - 17874098
AN - SCOPUS:36849058640
SN - 0340-6199
VL - 35
SP - 166
EP - 173
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 1
ER -