Left cardiac sympathetic denervation in the therapy of congenital long QT syndrome: A worldwide report

P. J. Schwartz; E. H. Locati; A. J. Moss; R. S. Crampton; R. Trazzi; U. Ruberti

Left cardiac sympathetic denervation in the therapy of congenital long QT syndrome: A worldwide report

P. J. Schwartz, E. H. Locati, A. J. Moss, R. S. Crampton, R. Trazzi, U. Ruberti

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Background. Long QT syndrome (LQTS) is a congenital disorder accompanied by a high incidence of sudden cardiac death. β-Adrenergic blockade is the therapy of choice, and it is successful in 75-80% of patients. For those in whom cardiac events (syncope or cardiac arrest) are not prevented by β-blockade, experimental studies suggest that left cardiac sympathetic denervation (LCSD) may be useful. Methods and Results. We identified 85 LQTS patients worldwide who underwent LCSD, and we provide here the first large-scale evaluation of its efficacy. The time interval between the first cardiac event and LCSD and the follow-up period after LCSD were similar (5.6±6.1 versus 5.9±5.7 years). The mean age of the patients at surgery was 20±13 years. LCSD was followed by highly significant (p

Original language	English
Pages (from-to)	503-511
Number of pages	9
Journal	Circulation
Volume	84
Issue number	2
Publication status	Published - 1991

Keywords

QT interval
Sudden cardiac death
Sympathetic nervous system

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

Cite this

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title = "Left cardiac sympathetic denervation in the therapy of congenital long QT syndrome: A worldwide report",

abstract = "Background. Long QT syndrome (LQTS) is a congenital disorder accompanied by a high incidence of sudden cardiac death. β-Adrenergic blockade is the therapy of choice, and it is successful in 75-80% of patients. For those in whom cardiac events (syncope or cardiac arrest) are not prevented by β-blockade, experimental studies suggest that left cardiac sympathetic denervation (LCSD) may be useful. Methods and Results. We identified 85 LQTS patients worldwide who underwent LCSD, and we provide here the first large-scale evaluation of its efficacy. The time interval between the first cardiac event and LCSD and the follow-up period after LCSD were similar (5.6±6.1 versus 5.9±5.7 years). The mean age of the patients at surgery was 20±13 years. LCSD was followed by highly significant (p",

keywords = "QT interval, Sudden cardiac death, Sympathetic nervous system",

author = "Schwartz, {P. J.} and Locati, {E. H.} and Moss, {A. J.} and Crampton, {R. S.} and R. Trazzi and U. Ruberti",

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T1 - Left cardiac sympathetic denervation in the therapy of congenital long QT syndrome

T2 - A worldwide report

AU - Schwartz, P. J.

AU - Locati, E. H.

AU - Moss, A. J.

AU - Crampton, R. S.

AU - Trazzi, R.

AU - Ruberti, U.

PY - 1991

Y1 - 1991

N2 - Background. Long QT syndrome (LQTS) is a congenital disorder accompanied by a high incidence of sudden cardiac death. β-Adrenergic blockade is the therapy of choice, and it is successful in 75-80% of patients. For those in whom cardiac events (syncope or cardiac arrest) are not prevented by β-blockade, experimental studies suggest that left cardiac sympathetic denervation (LCSD) may be useful. Methods and Results. We identified 85 LQTS patients worldwide who underwent LCSD, and we provide here the first large-scale evaluation of its efficacy. The time interval between the first cardiac event and LCSD and the follow-up period after LCSD were similar (5.6±6.1 versus 5.9±5.7 years). The mean age of the patients at surgery was 20±13 years. LCSD was followed by highly significant (p

AB - Background. Long QT syndrome (LQTS) is a congenital disorder accompanied by a high incidence of sudden cardiac death. β-Adrenergic blockade is the therapy of choice, and it is successful in 75-80% of patients. For those in whom cardiac events (syncope or cardiac arrest) are not prevented by β-blockade, experimental studies suggest that left cardiac sympathetic denervation (LCSD) may be useful. Methods and Results. We identified 85 LQTS patients worldwide who underwent LCSD, and we provide here the first large-scale evaluation of its efficacy. The time interval between the first cardiac event and LCSD and the follow-up period after LCSD were similar (5.6±6.1 versus 5.9±5.7 years). The mean age of the patients at surgery was 20±13 years. LCSD was followed by highly significant (p

KW - QT interval

KW - Sudden cardiac death

KW - Sympathetic nervous system

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Left cardiac sympathetic denervation in the therapy of congenital long QT syndrome: A worldwide report

Abstract

Keywords

ASJC Scopus subject areas

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