Late-onset OCD as presenting manifestation of semantic dementia

Sara Pompanin, Giulia Perini, Tommaso Toffanin, Francesca Gnoato, Diego Cecchin, Renzo Manara, Annachiara Cagnin

Research output: Contribution to journalArticlepeer-review


Semantic dementia (SD) is a neurodegenerative disease belonging to the spectrum of frontotemporal dementia that presents with loss of memory for words and prevalent left temporal pole atrophy. Behavioral disorders, particularly obsessive-compulsive symptoms, are frequent during the course of the disease. We describe a patient presenting with late-onset typical obsessive-compulsive disorder (OCD) that lasted for 10 years as an isolated condition before developing clinical and neuroimaging features of SD. This case alerts clinicians that late-onset OCD may be a psychiatric presentation of a neurodegenerative disorder such as frontotemporal dementia and requires an accurate diagnostic work-up.

Original languageEnglish
JournalGeneral Hospital Psychiatry
Issue number1
Publication statusPublished - Jan 2012


  • F-fluorodeoxyglucose-PET
  • Frontotemporal dementia
  • Obsessive Compulsive Disorder
  • Semantic dementia

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'Late-onset OCD as presenting manifestation of semantic dementia'. Together they form a unique fingerprint.

Cite this