TY - JOUR
T1 - Laser stimulation on bone defect healing
T2 - An in vitro study
AU - Guzzardella, G. A.
AU - Fini, M.
AU - Torricelli, P.
AU - Giavaresi, G.
AU - Giardino, R.
PY - 2002
Y1 - 2002
N2 - The aim of this in vitro study was to evaluate whether low-power laser (LPL) stimulation can accelerate bone healing. Bone defects of a standard area were created in the distal epiphysis of 12 femora explanted from six rats, and they were cultured in BGJb medium for 21 days. Six defects were treated daily with Ga-Al-As, 780 nm LPL for 10 consecutive days (lased group, LG), while the remainder were sham-treated (control group, CG). Alkaline phosphatase/total protein (ALP/TP), calcium (Ca), and nitric oxide (NO) were tested on days 7, 14 and 21 to monitor the metabolism of cultured bone. The percentage of healing of the defect area was determined by histomorphometric analysis. After 21 days significant increases were observed in ALP/TP in LG versus CG (p
AB - The aim of this in vitro study was to evaluate whether low-power laser (LPL) stimulation can accelerate bone healing. Bone defects of a standard area were created in the distal epiphysis of 12 femora explanted from six rats, and they were cultured in BGJb medium for 21 days. Six defects were treated daily with Ga-Al-As, 780 nm LPL for 10 consecutive days (lased group, LG), while the remainder were sham-treated (control group, CG). Alkaline phosphatase/total protein (ALP/TP), calcium (Ca), and nitric oxide (NO) were tested on days 7, 14 and 21 to monitor the metabolism of cultured bone. The percentage of healing of the defect area was determined by histomorphometric analysis. After 21 days significant increases were observed in ALP/TP in LG versus CG (p
KW - Bone healing
KW - Experiment
KW - Low-power laser
KW - Organ culture
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U2 - 10.1007/s101030200031
DO - 10.1007/s101030200031
M3 - Article
C2 - 12181636
AN - SCOPUS:0035990870
SN - 0268-8921
VL - 17
SP - 216
EP - 220
JO - Lasers in Medical Science
JF - Lasers in Medical Science
IS - 3
ER -