Large-cell medulloblastomas: A distinct variant with highly aggressive behavior

F. Giangaspero, L. Rigobello, M. Badiali, M. Loda, L. Andreini, G. Basso, F. Zorzi, A. Montaldi

Research output: Contribution to journalArticlepeer-review


We present four cases of infantile cerebellar neoplasms composed of cells with large vesicular nuclei with prominent nucleoli. All four cases were strongly immunoreactive for synaptophysin, and one case showed immunoreactivity for neurofilaments. Filter hybridization for N-myc and c-myc oncogenes showed a 27-fold c-myc amplification in one case. The cytogenetic analysis in this case showed Double-Minutes and isochromosome 17q. An intracerebral xenograft in nude mice obtained from one such tumor showed a similar morphology to that of the original tumor as well as strong immunoreactivity for synaptophysin and neurofilaments. All the neoplasms were characterized by highly aggressive behavior leading to early cerebrospinal fluid dissemination despite radiotherapy and chemotherapy. We conclude that large cell medulloblastoma represents a distinct and more aggressive variant of medulloblastoma that requires more aggressive therapy.

Original languageEnglish
Pages (from-to)687-693
Number of pages7
JournalAmerican Journal of Surgical Pathology
Issue number7
Publication statusPublished - 1992


  • Central nervous system
  • Medulloblastoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine


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