Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease

Andrea Tedde; Mario Rotondi; Elena Cellini; Silvia Bagnoli; Laura Muratore; Benedetta Nacmias; Sandro Sorbi

doi:10.1016/j.neurobiolaging.2005.03.029

Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease

Andrea Tedde, Mario Rotondi, Elena Cellini, Silvia Bagnoli, Laura Muratore, Benedetta Nacmias, Sandro Sorbi

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

Recent studies have provided evidence toward the possible involvement of brain cholesterol homeostasis in late-onset Alzheimer's disease (LOAD). We analyzed an intronic T → C substitution (rs 754203) of the cholesterol 24S-hydroxylase (CYP46) gene, encoding an enzyme acting on brain cholesterol turnover, which has been recently associated with an increased risk of AD, dependent or not on Apolipoprotein E (ApoE) genotype. No significant association was found for the CYP46 polymorphism in LOAD compared to the controls, even after stratification for the presence/absence of the ApoE*4 allele. Our data do not support a role of the CYP46 polymorphism as a possible susceptibility factor for developing AD.

Original language	English
Journal	Neurobiology of Aging
Volume	27
Issue number	5
DOIs	https://doi.org/10.1016/j.neurobiolaging.2005.03.029
Publication status	Published - May 2006

Keywords

Alzheimer's disease
Apolipoprotein E
Cholesterol 24S-hydroxylase
Genetic factors
Polymorphism

ASJC Scopus subject areas

Clinical Neurology
Biological Psychiatry
Developmental Neuroscience
Neurology
Psychology(all)

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10.1016/j.neurobiolaging.2005.03.029

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title = "Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease",

abstract = "Recent studies have provided evidence toward the possible involvement of brain cholesterol homeostasis in late-onset Alzheimer's disease (LOAD). We analyzed an intronic T → C substitution (rs 754203) of the cholesterol 24S-hydroxylase (CYP46) gene, encoding an enzyme acting on brain cholesterol turnover, which has been recently associated with an increased risk of AD, dependent or not on Apolipoprotein E (ApoE) genotype. No significant association was found for the CYP46 polymorphism in LOAD compared to the controls, even after stratification for the presence/absence of the ApoE*4 allele. Our data do not support a role of the CYP46 polymorphism as a possible susceptibility factor for developing AD.",

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T1 - Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease

AU - Tedde, Andrea

AU - Rotondi, Mario

AU - Cellini, Elena

AU - Bagnoli, Silvia

AU - Muratore, Laura

AU - Nacmias, Benedetta

AU - Sorbi, Sandro

PY - 2006/5

Y1 - 2006/5

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AB - Recent studies have provided evidence toward the possible involvement of brain cholesterol homeostasis in late-onset Alzheimer's disease (LOAD). We analyzed an intronic T → C substitution (rs 754203) of the cholesterol 24S-hydroxylase (CYP46) gene, encoding an enzyme acting on brain cholesterol turnover, which has been recently associated with an increased risk of AD, dependent or not on Apolipoprotein E (ApoE) genotype. No significant association was found for the CYP46 polymorphism in LOAD compared to the controls, even after stratification for the presence/absence of the ApoE*4 allele. Our data do not support a role of the CYP46 polymorphism as a possible susceptibility factor for developing AD.

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Cholesterol 24S-hydroxylase

KW - Genetic factors

KW - Polymorphism

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JO - Neurobiology of Aging

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Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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