Laboratory markers of hypercoagulability

M. L. Rossi, P. A. Merlini, D. Ardissino

Research output: Contribution to journalArticlepeer-review


Investigations carried out over the last 40 years have demonstrated that coronary artery thrombosis is the critical event underlying myocardial infarction and unstable angina. The existence of a prolonged hypercoagulable state preceding the thrombotic event has been postulated for some time and significant associations have been established between the plasma concentrations of a number of hemostatic variables and the frequency of myocardial infarction. High plasma fibrinogen, factor VII/VIIa, tissue-type plasminogen activator and plasminogen activator inhibitor levels have been associated with at least as great a risk of developing myocardial (re)infarction or sudden death as high cholesterol levels, especially in the young. In the last year more sensitive assays have been developed, and they should allow a precise biochemical definition of hypercoagulable states. The significance of these new assays and their role in defining a hypercoagulable state in different conditions are analyzed.

Original languageEnglish
Pages (from-to)490-494
Number of pages5
JournalItalian Heart Journal
Issue number7
Publication statusPublished - 2001


  • Coagulation
  • Coronary artery disease
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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