KSRP Controls Pleiotropic Cellular Functions

Roberto Gherzi; Ching Yi Chen; Andres Ramos; Paola Briata

doi:10.1016/j.semcdb.2014.05.004

KSRP Controls Pleiotropic Cellular Functions

Roberto Gherzi, Ching Yi Chen, Andres Ramos, Paola Briata

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

The single-strand-RNA binding protein KSRP is able to negatively regulate gene expression operating with at least two distinct and integrated postranscriptional mechanisms: (i) by promoting decay of unstable mRNAs and (ii) by favoring maturation from precursors of select microRNAs (miRNAs) including the prototypical tumor suppressor let-7. Studies performed in primary and cultured cells as well as in mice proved that the ability of KSRP to integrate different levels of gene expression is required for proper immune response, lipid metabolism, cell-fate decisions, tissue regeneration, and DNA damage response.

Original language	English
Pages (from-to)	2-8
Number of pages	7
Journal	Seminars in Cell and Developmental Biology
Volume	34
DOIs	https://doi.org/10.1016/j.semcdb.2014.05.004
Publication status	Published - Oct 1 2014

Keywords

Cell differentiation
Immune response
KH domain
Lipid metabolism
MicroRNA maturation
MRNA decay

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1016/j.semcdb.2014.05.004

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title = "KSRP Controls Pleiotropic Cellular Functions",

abstract = "The single-strand-RNA binding protein KSRP is able to negatively regulate gene expression operating with at least two distinct and integrated postranscriptional mechanisms: (i) by promoting decay of unstable mRNAs and (ii) by favoring maturation from precursors of select microRNAs (miRNAs) including the prototypical tumor suppressor let-7. Studies performed in primary and cultured cells as well as in mice proved that the ability of KSRP to integrate different levels of gene expression is required for proper immune response, lipid metabolism, cell-fate decisions, tissue regeneration, and DNA damage response.",

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author = "Roberto Gherzi and Chen, {Ching Yi} and Andres Ramos and Paola Briata",

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AU - Gherzi, Roberto

AU - Chen, Ching Yi

AU - Ramos, Andres

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N2 - The single-strand-RNA binding protein KSRP is able to negatively regulate gene expression operating with at least two distinct and integrated postranscriptional mechanisms: (i) by promoting decay of unstable mRNAs and (ii) by favoring maturation from precursors of select microRNAs (miRNAs) including the prototypical tumor suppressor let-7. Studies performed in primary and cultured cells as well as in mice proved that the ability of KSRP to integrate different levels of gene expression is required for proper immune response, lipid metabolism, cell-fate decisions, tissue regeneration, and DNA damage response.

AB - The single-strand-RNA binding protein KSRP is able to negatively regulate gene expression operating with at least two distinct and integrated postranscriptional mechanisms: (i) by promoting decay of unstable mRNAs and (ii) by favoring maturation from precursors of select microRNAs (miRNAs) including the prototypical tumor suppressor let-7. Studies performed in primary and cultured cells as well as in mice proved that the ability of KSRP to integrate different levels of gene expression is required for proper immune response, lipid metabolism, cell-fate decisions, tissue regeneration, and DNA damage response.

KW - Cell differentiation

KW - Immune response

KW - KH domain

KW - Lipid metabolism

KW - MicroRNA maturation

KW - MRNA decay

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KSRP Controls Pleiotropic Cellular Functions

Abstract

Keywords

ASJC Scopus subject areas

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