TY - JOUR
T1 - Joint effect of insulin signaling genes on cardiovascular events and on whole body and endothelial insulin resistance
AU - Bacci, Simonetta
AU - Prudente, Sabrina
AU - Copetti, Massimiliano
AU - Spoto, Belinda
AU - Rizza, Stefano
AU - Baratta, Roberto
AU - Di Pietro, Natalia
AU - Morini, Eleonora
AU - Di Paola, Rosa
AU - Testa, Alessandra
AU - Mallamaci, Francesca
AU - Tripepi, Giovanni
AU - Zhang, Yuan Yuan
AU - Mercuri, Luana
AU - Di Silvestre, Sara
AU - Lauro, Renato
AU - Malatino, Lorenzo
AU - Consoli, Agostino
AU - Pellegrini, Fabio
AU - Pandolfi, Assunta
AU - Frittitta, Lucia
AU - Zoccali, Carmine
AU - Federici, Massimo
AU - Doria, Alessandro
AU - Trischitta, Vincenzo
PY - 2013/1
Y1 - 2013/1
N2 - Objective: Insulin resistance (IR) and cardiovascular disease (CVD) share a common soil. We investigated the combined role of single nucleotide polymorphisms (SNPs) affecting insulin signaling (ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; TRIB3 Q84R, rs2295490) on CVD, age at myocardial infarction (MI), in vivo insulin sensitivity and in vitro insulin-stimulated nitric oxide synthase (NOS) activity. Design and setting: 1. We first studied, incident cardiovascular events (a composite endpoint comprising myocardial infarction-MI, stroke and cardiovascular death) in 733 patients (2186 person-years, 175 events). 2. In a replication attempt, age at MI was tested in 331 individuals. 3. OGTT-derived insulin sensitivity index (ISI) was assessed in 829 individuals with fasting glucose
AB - Objective: Insulin resistance (IR) and cardiovascular disease (CVD) share a common soil. We investigated the combined role of single nucleotide polymorphisms (SNPs) affecting insulin signaling (ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; TRIB3 Q84R, rs2295490) on CVD, age at myocardial infarction (MI), in vivo insulin sensitivity and in vitro insulin-stimulated nitric oxide synthase (NOS) activity. Design and setting: 1. We first studied, incident cardiovascular events (a composite endpoint comprising myocardial infarction-MI, stroke and cardiovascular death) in 733 patients (2186 person-years, 175 events). 2. In a replication attempt, age at MI was tested in 331 individuals. 3. OGTT-derived insulin sensitivity index (ISI) was assessed in 829 individuals with fasting glucose
KW - Genetic susceptibility
KW - Insulin dependent endothelial function
KW - Insulin sensitivity
KW - Nonsynonymous polymorphism
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U2 - 10.1016/j.atherosclerosis.2012.10.035
DO - 10.1016/j.atherosclerosis.2012.10.035
M3 - Article
C2 - 23107043
AN - SCOPUS:84871377335
SN - 0021-9150
VL - 226
SP - 140
EP - 145
JO - Atherosclerosis
JF - Atherosclerosis
IS - 1
ER -