Isolated office hypertension: A 3-year follow-up study

Anna M. Grandi, Francesco Solbiati, Emanuela Laurita, Elena Cassinerio, Chiara Marchesi, Francesca Piperno, Andrea Maresca, Luigina Guasti, Achille Venco

Research output: Contribution to journalArticlepeer-review


The study aimed to evaluate, over a 3-year period, the progression towards sustained hypertension and left ventricular (LV) changes in patients with isolated office (IO) hypertension (office BP > 140 and/or 90 mmHg, daytime BP <130/80 mmHg). After 3 years from the basal evaluation, 38 subjects with basal normal BP and 42 subjects with basal IO hypertension underwent a second 24-h BP monitoring and echocardiography; 19 patients of the basal IO hypertension group were not revaluated because they had already developed ambulatory hypertension and were on antihypertensive treatment. At the second evaluation, the 38 normotensive subjects had unchanged BP and LV parameters; 25 IO hypertensives have developed sustained hypertension. Considering them together with the 19 patients already treated, 72% of 61 IO hypertensives developed ambulatory hypertension over a 3-year period. The patients who subsequently developed hypertension differed from the group who did not only for lower basal values of LV diastolic parameters; all the patients with basal LV hypertrophy and/or preclinical diastolic impairment subsequently developed sustained hypertension. In conclusion, IO hypertensive patients show a high rate of progression towards sustained hypertension. Basal LV hypertrophy and/or preclinical diastolic dysfunction were the only markers of a greater risk of becoming hypertensives.

Original languageEnglish
Pages (from-to)298-305
Number of pages8
JournalBlood Pressure
Issue number5
Publication statusPublished - 2005


  • Ambulatory BP monitoring
  • Diastolic function
  • Isolated office hypertension
  • Left ventricular hypertrophy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine


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