TY - JOUR
T1 - Is there a rationale for pulmonary rehabilitation following successful chemotherapy for tuberculosis?
AU - Muñoz-Torrico, Marcela
AU - Rendon, Adrian
AU - Centis, Rosella
AU - D’Ambrosio, Lia
AU - Fuentes, Zhenia
AU - Torres-Duque, Carlos
AU - Mello, Fernanda
AU - Dalcolmo, Margareth
AU - Pérez-Padilla, Rogelio
AU - Spanevello, Antonio
AU - Migliori, Giovanni Battista
PY - 2016/9/1
Y1 - 2016/9/1
N2 - The role of tuberculosis as a public health care priority and the availability of diagnostic tools to evaluate functional status (spirometry, plethysmography, and DLCO determination), arterial blood gases, capacity to perform exercise, lesions (chest X-ray and CT), and quality of life justify the effort to consider what needs to be done when patients have completed their treatment. To our knowledge, no review has ever evaluated this topic in a comprehensive manner. Our objective was to review the available evidence on this topic and draw conclusions regarding the future role of the “post-tuberculosis treatment” phase, which will potentially affect several million cases every year. We carried out a non-systematic literature review based on a PubMed search using specific keywords (various combinations of the terms “tuberculosis”, “rehabilitation”, “multidrug-resistant tuberculosis”, “pulmonary disease”, “obstructive lung disease”, and “lung volume measurements”). The reference lists of the most important studies were retrieved in order to improve the sensitivity of the search. Manuscripts written in English, Spanish, and Russian were selected. The main areas of interest were tuberculosis sequelae following tuberculosis diagnosis and treatment; “destroyed lung”; functional evaluation of sequelae; pulmonary rehabilitation interventions (physiotherapy, long-term oxygen therapy, and ventilation); and multidrug-resistant tuberculosis. The evidence found suggests that tuberculosis is definitively responsible for functional sequelae, primarily causing an obstructive pattern on spirometry (but also restrictive and mixed patterns), and that there is a rationale for pulmonary rehabilitation. We also provide a list of variables that should be discussed in future studies on pulmonary rehabilitation in patients with post-tuberculosis sequelae.
AB - The role of tuberculosis as a public health care priority and the availability of diagnostic tools to evaluate functional status (spirometry, plethysmography, and DLCO determination), arterial blood gases, capacity to perform exercise, lesions (chest X-ray and CT), and quality of life justify the effort to consider what needs to be done when patients have completed their treatment. To our knowledge, no review has ever evaluated this topic in a comprehensive manner. Our objective was to review the available evidence on this topic and draw conclusions regarding the future role of the “post-tuberculosis treatment” phase, which will potentially affect several million cases every year. We carried out a non-systematic literature review based on a PubMed search using specific keywords (various combinations of the terms “tuberculosis”, “rehabilitation”, “multidrug-resistant tuberculosis”, “pulmonary disease”, “obstructive lung disease”, and “lung volume measurements”). The reference lists of the most important studies were retrieved in order to improve the sensitivity of the search. Manuscripts written in English, Spanish, and Russian were selected. The main areas of interest were tuberculosis sequelae following tuberculosis diagnosis and treatment; “destroyed lung”; functional evaluation of sequelae; pulmonary rehabilitation interventions (physiotherapy, long-term oxygen therapy, and ventilation); and multidrug-resistant tuberculosis. The evidence found suggests that tuberculosis is definitively responsible for functional sequelae, primarily causing an obstructive pattern on spirometry (but also restrictive and mixed patterns), and that there is a rationale for pulmonary rehabilitation. We also provide a list of variables that should be discussed in future studies on pulmonary rehabilitation in patients with post-tuberculosis sequelae.
KW - Diagnostic imaging
KW - Quality of life
KW - Respiratory function tests
KW - Tuberculosis/complications
KW - Tuberculosis/rehabilitation
KW - Tuberculosis/therapy
UR - http://www.scopus.com/inward/record.url?scp=84994099405&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84994099405&partnerID=8YFLogxK
U2 - 10.1590/S1806-37562016000000226
DO - 10.1590/S1806-37562016000000226
M3 - Review article
AN - SCOPUS:84994099405
SN - 1806-3713
VL - 42
SP - 374
EP - 385
JO - Jornal Brasileiro de Pneumologia
JF - Jornal Brasileiro de Pneumologia
IS - 5
ER -