Is the isolated animal a possible model for phobia and anxiety?

Silvio Garattini, Luigi Valzelli

Research output: Contribution to journalArticlepeer-review


1. 1. Isolated animals develop a complex symptopathology which can be characterized both behaviorally and neurochemically. 2. 2. The main behavioral features include: compulsive aggression, impairment of learning, exploration and sexual behavior, while the main neurochemical features include a decrease of brain tryptophan content and of brain serotonin turnover and an increased brain dopamine turnover. 3. 3. Isolated aggressive mice are differently sensitive than grouped animals and respond differently to several psychotropic drugs, tricyclic antidepressants, betablockers and benzodiazepines. 4. 4. The results obtained will be discussed in the frame of the possibility of utilizing these animals models to study drugs active on anxiety and phobia.

Original languageEnglish
Pages (from-to)159-165
Number of pages7
JournalProgress in Neuro-Psychopharmacology
Issue number2
Publication statusPublished - 1981


  • aggression
  • antianxious drugs
  • antidepressants
  • emotional behavior
  • phobia
  • socio-environmental deprivation

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Medicine(all)


Dive into the research topics of 'Is the isolated animal a possible model for phobia and anxiety?'. Together they form a unique fingerprint.

Cite this