Is it time to revise antiretrovirals dosing? A pharmacokinetic viewpoint

Dario Cattaneo; Sara Baldelli; Simone Castoldi; Nitin Charbe; Valeria Cozzi; Serena Fucile; Emilio Clementi

doi:10.1097/QAD.0000000000000440

Is it time to revise antiretrovirals dosing? A pharmacokinetic viewpoint

Dario Cattaneo, Sara Baldelli, Simone Castoldi, Nitin Charbe, Valeria Cozzi, Serena Fucile, Emilio Clementi

Istituto "Eugenio Medea" - Associazione La Nostra Famiglia

Research output: Contribution to journal › Article › peer-review

Abstract

We document our experience with therapeutic drug monitoring (TDM) of antiretroviral agents (1807 determinations) carried out as day-by-day clinical practice for the optimization of drug dosing in HIV-infected patients. A significant proportion of patients had lopinavir, atazanavir and nevirapine trough concentrations exceeding the upper therapeutic threshold. Further studies are needed to identify good candidates/drugs for TDM, eventually allowing the selection of patients who may benefit from TDM-driven adjustments in antiretrovirals dosage.

Original language	English
Pages (from-to)	2477-2480
Number of pages	4
Journal	AIDS (London, England)
Volume	28
Issue number	16
DOIs	https://doi.org/10.1097/QAD.0000000000000440
Publication status	Published - 2014

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases
Medicine(all)

Access to Document

10.1097/QAD.0000000000000440

Cite this

@article{64ea25b60a79459e82d06a25161e3f2e,

title = "Is it time to revise antiretrovirals dosing? A pharmacokinetic viewpoint",

abstract = "We document our experience with therapeutic drug monitoring (TDM) of antiretroviral agents (1807 determinations) carried out as day-by-day clinical practice for the optimization of drug dosing in HIV-infected patients. A significant proportion of patients had lopinavir, atazanavir and nevirapine trough concentrations exceeding the upper therapeutic threshold. Further studies are needed to identify good candidates/drugs for TDM, eventually allowing the selection of patients who may benefit from TDM-driven adjustments in antiretrovirals dosage.",

author = "Dario Cattaneo and Sara Baldelli and Simone Castoldi and Nitin Charbe and Valeria Cozzi and Serena Fucile and Emilio Clementi",

year = "2014",

doi = "10.1097/QAD.0000000000000440",

language = "English",

volume = "28",

pages = "2477--2480",

journal = "AIDS",

issn = "0269-9370",

publisher = "NLM (Medline)",

number = "16",

}

TY - JOUR

T1 - Is it time to revise antiretrovirals dosing? A pharmacokinetic viewpoint

AU - Cattaneo, Dario

AU - Baldelli, Sara

AU - Castoldi, Simone

AU - Charbe, Nitin

AU - Cozzi, Valeria

AU - Fucile, Serena

AU - Clementi, Emilio

PY - 2014

Y1 - 2014

N2 - We document our experience with therapeutic drug monitoring (TDM) of antiretroviral agents (1807 determinations) carried out as day-by-day clinical practice for the optimization of drug dosing in HIV-infected patients. A significant proportion of patients had lopinavir, atazanavir and nevirapine trough concentrations exceeding the upper therapeutic threshold. Further studies are needed to identify good candidates/drugs for TDM, eventually allowing the selection of patients who may benefit from TDM-driven adjustments in antiretrovirals dosage.

AB - We document our experience with therapeutic drug monitoring (TDM) of antiretroviral agents (1807 determinations) carried out as day-by-day clinical practice for the optimization of drug dosing in HIV-infected patients. A significant proportion of patients had lopinavir, atazanavir and nevirapine trough concentrations exceeding the upper therapeutic threshold. Further studies are needed to identify good candidates/drugs for TDM, eventually allowing the selection of patients who may benefit from TDM-driven adjustments in antiretrovirals dosage.

UR - http://www.scopus.com/inward/record.url?scp=84916208892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84916208892&partnerID=8YFLogxK

U2 - 10.1097/QAD.0000000000000440

DO - 10.1097/QAD.0000000000000440

M3 - Article

C2 - 25392858

AN - SCOPUS:84916208892

SN - 0269-9370

VL - 28

SP - 2477

EP - 2480

JO - AIDS

JF - AIDS

IS - 16

ER -

Is it time to revise antiretrovirals dosing? A pharmacokinetic viewpoint

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this