Is circulating D-dimer level a better prognostic indicator than CEA in resectable colorectal cancer? Our experience on 199 cases

Corrado Pedrazzani; Guido Cerullo; Daniele Marrelli; Eduardo Fernandes; Filippo Carlucci; Giovanni Corso; Francesca Bettarini; Alfonso De Stefano; Franco Roviello

Is circulating D-dimer level a better prognostic indicator than CEA in resectable colorectal cancer? Our experience on 199 cases

Corrado Pedrazzani, Guido Cerullo, Daniele Marrelli, Eduardo Fernandes, Filippo Carlucci, Giovanni Corso, Francesca Bettarini, Alfonso De Stefano, Franco Roviello

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To evaluate the clinical impact of D-dimer (DD) as a tumor marker in patients with colorectal cancer (CRC). The prognostic value of preoperative DD measurement was assessed in relation to carcinoembryonic antigen (CEA) levels. Methods: DD and CEA levels were measured preoperatively in 199 patients who underwent resection for CRC and the results were analyzed statistically. Results: The preoperative mean (±SD) levels of DD and CEA were 347.5 (±940.1) ng/mL and 106.4 (±1099.2) ng/mL. The DD level was significantly correlated with the nature of surgery (emergency vs. elective; p=0.002), presence of residual tumor (R1-2 vs R0; p=0.037), and tumor diameter (p

Original language	English
Pages (from-to)	171-176
Number of pages	6
Journal	International Journal of Biological Markers
Volume	25
Issue number	3
Publication status	Published - Jul 2010

Keywords

Carcinoembryonic antigen
Colorectal carcinoma
D-dimer
Prognosis

ASJC Scopus subject areas

Clinical Biochemistry
Cancer Research
Oncology
Pathology and Forensic Medicine

Cite this

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title = "Is circulating D-dimer level a better prognostic indicator than CEA in resectable colorectal cancer? Our experience on 199 cases",

abstract = "Purpose: To evaluate the clinical impact of D-dimer (DD) as a tumor marker in patients with colorectal cancer (CRC). The prognostic value of preoperative DD measurement was assessed in relation to carcinoembryonic antigen (CEA) levels. Methods: DD and CEA levels were measured preoperatively in 199 patients who underwent resection for CRC and the results were analyzed statistically. Results: The preoperative mean (±SD) levels of DD and CEA were 347.5 (±940.1) ng/mL and 106.4 (±1099.2) ng/mL. The DD level was significantly correlated with the nature of surgery (emergency vs. elective; p=0.002), presence of residual tumor (R1-2 vs R0; p=0.037), and tumor diameter (p",

keywords = "Carcinoembryonic antigen, Colorectal carcinoma, D-dimer, Prognosis",

author = "Corrado Pedrazzani and Guido Cerullo and Daniele Marrelli and Eduardo Fernandes and Filippo Carlucci and Giovanni Corso and Francesca Bettarini and {De Stefano}, Alfonso and Franco Roviello",

year = "2010",

month = jul,

language = "English",

volume = "25",

pages = "171--176",

journal = "International Journal of Biological Markers",

issn = "0393-6155",

publisher = "Wichtig Publishing Srl",

number = "3",

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TY - JOUR

T1 - Is circulating D-dimer level a better prognostic indicator than CEA in resectable colorectal cancer? Our experience on 199 cases

AU - Pedrazzani, Corrado

AU - Cerullo, Guido

AU - Marrelli, Daniele

AU - Fernandes, Eduardo

AU - Carlucci, Filippo

AU - Corso, Giovanni

AU - Bettarini, Francesca

AU - De Stefano, Alfonso

AU - Roviello, Franco

PY - 2010/7

Y1 - 2010/7

N2 - Purpose: To evaluate the clinical impact of D-dimer (DD) as a tumor marker in patients with colorectal cancer (CRC). The prognostic value of preoperative DD measurement was assessed in relation to carcinoembryonic antigen (CEA) levels. Methods: DD and CEA levels were measured preoperatively in 199 patients who underwent resection for CRC and the results were analyzed statistically. Results: The preoperative mean (±SD) levels of DD and CEA were 347.5 (±940.1) ng/mL and 106.4 (±1099.2) ng/mL. The DD level was significantly correlated with the nature of surgery (emergency vs. elective; p=0.002), presence of residual tumor (R1-2 vs R0; p=0.037), and tumor diameter (p

AB - Purpose: To evaluate the clinical impact of D-dimer (DD) as a tumor marker in patients with colorectal cancer (CRC). The prognostic value of preoperative DD measurement was assessed in relation to carcinoembryonic antigen (CEA) levels. Methods: DD and CEA levels were measured preoperatively in 199 patients who underwent resection for CRC and the results were analyzed statistically. Results: The preoperative mean (±SD) levels of DD and CEA were 347.5 (±940.1) ng/mL and 106.4 (±1099.2) ng/mL. The DD level was significantly correlated with the nature of surgery (emergency vs. elective; p=0.002), presence of residual tumor (R1-2 vs R0; p=0.037), and tumor diameter (p

KW - Carcinoembryonic antigen

KW - Colorectal carcinoma

KW - D-dimer

KW - Prognosis

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SN - 0393-6155

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JO - International Journal of Biological Markers

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Is circulating D-dimer level a better prognostic indicator than CEA in resectable colorectal cancer? Our experience on 199 cases

Abstract

Keywords

ASJC Scopus subject areas

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