TY - JOUR
T1 - Irreversible disability and tissue loss in multiple sclerosis
T2 - A conventional and magnetization transfer magnetic resonance imaging study of the optic nerves
AU - Inglese, Matilde
AU - Ghezzi, Angelo
AU - Bianchi, Stefania
AU - Gerevini, Simonetta
AU - Sormani, Maria Pia
AU - Martinelli, Vittorio
AU - Comi, Giancarlo
AU - Filippi, Massimo
PY - 2002
Y1 - 2002
N2 - Objectives: To assess, by magnetic resonance imaging, the volumes and magnetization transfer ratio (MTR) values of optic nerves (ONs) from patients with multiple sclerosis (MS) who had incomplete or no visual recovery after optic neuritis; and to compare these quantities with those derived from ONs from patients with MS who showed a marked clinical recovery after optic neuritis, ONs from healthy volunteers, and ONs from patients with Leber hereditary optic neuropathy (LHON). Methods: Conventional and magnetization transfer magnetic resonance images of the ONs were obtained from 30 patients with MS, 18 healthy volunteers, and 10 patients with LHON. The ON from patients with MS were classified as clinically unaffected (n = 18); clinically affected with recovery (n = 20; visual acuity ≥20/25 at least 6 months after optic neuritis); and clinically affected with incomplete or no recovery (n = 22; visual acuity
AB - Objectives: To assess, by magnetic resonance imaging, the volumes and magnetization transfer ratio (MTR) values of optic nerves (ONs) from patients with multiple sclerosis (MS) who had incomplete or no visual recovery after optic neuritis; and to compare these quantities with those derived from ONs from patients with MS who showed a marked clinical recovery after optic neuritis, ONs from healthy volunteers, and ONs from patients with Leber hereditary optic neuropathy (LHON). Methods: Conventional and magnetization transfer magnetic resonance images of the ONs were obtained from 30 patients with MS, 18 healthy volunteers, and 10 patients with LHON. The ON from patients with MS were classified as clinically unaffected (n = 18); clinically affected with recovery (n = 20; visual acuity ≥20/25 at least 6 months after optic neuritis); and clinically affected with incomplete or no recovery (n = 22; visual acuity
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M3 - Article
C2 - 11843696
AN - SCOPUS:0036126863
SN - 0003-9942
VL - 59
SP - 250
EP - 255
JO - Archives of Neurology
JF - Archives of Neurology
IS - 2
ER -